Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 5/20 | 0.74 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.74 |
| ▸ | DYRK1B | Q9Y463 | 4/20 | 0.74 |
| ▸ | DYRK2 | Q92630 | 3/20 | 0.74 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.74 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.74 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.74 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.74 |
| ▸ | CLK3 | P49761 | 3/20 | 0.74 |
| ▸ | PIM1 | P11309 | 3/20 | 0.74 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.74 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.74 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.74 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.74 |
| ▸ | MYLK2 | Q9H1R3 | 1/20 | 0.74 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.74 |
| ▸ | DYRK3 | O43781 | 5/20 | 0.62 |
| ▸ | CDK1 | P06493 | 4/20 | 0.59 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.59 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL497023 | 1.00 | CLK1 (0.74) | CLK1DYRK1ADYRK1BDYRK2PIK3CD | |
| SCHEMBL2882800 | 0.88 | PIM1 (0.79) | CLK1DYRK1ADYRK1BDYRK2PIK3CD | |
| SCHEMBL2882802 | 0.88 | PIM1 (0.79) | CLK1DYRK1ADYRK1BDYRK2PIK3CD | |
| SCHEMBL497536 | 0.85 | PIM1 (1.00) | CLK1DYRK1ADYRK1BDYRK2PIK3CD | |
| SCHEMBL497535 | 0.85 | PIM1 (1.00) | CLK1DYRK1ADYRK1BDYRK2PIK3CD | |
| SCHEMBL2883201 | 0.84 | CLK1 (0.77) | CLK1DYRK1ADYRK1BDYRK2PIK3CD | |
| SCHEMBL2883203 | 0.84 | CLK1 (0.77) | CLK1DYRK1ADYRK1BDYRK2PIK3CD | |
| SCHEMBL6418533 | 0.81 | MEN1 (0.51) | CLK1DYRK1ADYRK1BDYRK2PIK3CD | |
| Trifluoroacetic Acid SCHEMBL2423270 | 0.79 | PIM1 (0.65) | CLK1DYRK1ADYRK1BDYRK2PIK3CD | |
| Trifluoroacetic Acid SCHEMBL2423268 | 0.79 | PIM1 (0.65) | CLK1DYRK1ADYRK1BDYRK2PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7846925-B2 | Azolidinone-vinyl fused-benzene derivatives | MERCK SERONO SA (CH) | 2010-12-07 | — | — | US | claimed |
| US-20090042773-A1 | P13 kinase gamma inhibitors for the treatment of anaemia | MERCK SERONO SA (CH) | 2009-02-12 | — | — | US | claimed |
| EP-1807075-A2 | PI3 KINASE GAMMA INHIBITORS FOR THE TREATMENT OF ANAEMIA | Applied Research Systems ARS Holding N.V. (AN) | 2007-07-18 | — | — | EP | claimed |
| US-20060122176-A1 | Azolidinone-vinyl fused-benzene derivatives | MERCK SERONO SA (CH) | 2006-06-08 | — | — | US | claimed |
| WO-2006040318-A2 | PI3 KINASE GAMMA INHIBITORS FOR THE TREATMENT OF ANAEMIA | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2006-04-20 | — | — | WO | claimed |
| US-20050222225-A1 | Use of compounds for increasing spermatozoa motility | APPLIED RESEARCH SYSTEMS ARS HOLDING NV (NL) | 2005-10-06 | — | — | US | claimed |
| US-8106214-B2 | 2-imino-4-(thio) oxo-5-polycyclovinylazolines for use as PI3 kinase inhibitors | MERCK SERONO SA (CH) | 2012-01-31 | — | — | US | disclosed |
| US-8106214-B2 | 2-imino-4-(thio) oxo-5-polycyclovinylazolines for use as PI3 kinase inhibitors | MERCK SERONO SA (CH) | 2012-01-31 | — | — | US | disclosed |
| US-8106214-B2 | 2-imino-4-(thio) oxo-5-polycyclovinylazolines for use as PI3 kinase inhibitors | MERCK SERONO SA (CH) | 2012-01-31 | — | — | US | disclosed |
| US-7846925-B2 | Azolidinone-vinyl fused-benzene derivatives | MERCK SERONO SA (CH) | 2010-12-07 | — | — | US | disclosed |
| US-7846925-B2 | Azolidinone-vinyl fused-benzene derivatives | MERCK SERONO SA (CH) | 2010-12-07 | — | — | US | disclosed |
| US-7846925-B2 | Azolidinone-vinyl fused-benzene derivatives | MERCK SERONO SA (CH) | 2010-12-07 | — | — | US | disclosed |
| US-20090306069-A1 | AZOLIDINONE-VINYL FUSED-BENZENE DERIVATIVES | LABORATOIRES SERONO S.A. (CH) | 2009-12-10 | — | — | US | disclosed |
| US-20070021447-A1 | 2-Imino-4-(thio)oxo-5-poly cyclovinylazolines for use as p13 kinase ihibitors | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2007-01-25 | — | — | US | disclosed |
| US-20060122176-A1 | Azolidinone-vinyl fused-benzene derivatives | MERCK SERONO SA (CH) | 2006-06-08 | — | — | US | disclosed |
| US-20050222225-A1 | Use of compounds for increasing spermatozoa motility | APPLIED RESEARCH SYSTEMS ARS HOLDING NV (NL) | 2005-10-06 | — | — | US | disclosed |
| EP-1549644-A1 | AZOLIDINONE-VINYL FUSED-BENZENE DERIVATIVES | Applied Research Systems ARS Holding N.V. (AN) | 2005-07-06 | — | — | EP | disclosed |
| EP-1531813-A1 | USE OF COMPOUNDS FOR INCREASING SPERMATOZOA MOTILITY | Applied Research Systems ARS Holding N.V. (AN) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004007491-A1 | AZOLIDINONE-VINYL FUSED-BENZENE DERIVATIVES | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2004-01-22 | — | — | WO | disclosed |
| WO-2004006916-A1 | USE OF COMPOUNDS FOR INCREASING SPERMATOZOA MOTILITY | APPLIED RESEARCH SYSTEMS ARS HOLDING NV (AN) | 2004-01-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306069-A1 | AZOLIDINONE-VINYL FUSED-BENZENE DERIVATIVES | ZAP70, BRCA1, ZYX | CLK1 4202/4885DYRK1A 3161/4885DYRK1B 2749/4885 |
| US-20090042773-A1 | P13 kinase gamma inhibitors for the treatment of anaemia | PDPK1, PRKD3, PRKD1 | CLK1 826/4885DYRK1A 362/4885DYRK1B 389/4885 |
| US-20070021447-A1 | 2-Imino-4-(thio)oxo-5-poly cyclovinylazolines for use as p13 kinase ihibitors | PI4K2B, PI4KA, PTK2B | CLK1 1008/4885DYRK1A 2093/4885DYRK1B 1813/4885 |
| US-20050222225-A1 | Use of compounds for increasing spermatozoa motility | CATSPER1, PI4KB, MAN2B2 | CLK1 843/4885DYRK1A 4508/4885DYRK1B 4430/4885 |
| US-20060122176-A1 | Azolidinone-vinyl fused-benzene derivatives | BRCA1, ZAP70, F13B | CLK1 4147/4885DYRK1A 3215/4885DYRK1B 2890/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.