Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | BLM | P54132 | 10/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.53 |
| ▸ | HTT | P42858 | 4/20 | 0.53 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24233006 | 0.86 | KMT2A (0.58) | KMT2AMEN1BLMKDM4EHTT | |
| SCHEMBL24232866 | 0.83 | KMT2A (0.75) | KMT2AMEN1BLMKDM4EHTT | |
| SCHEMBL24233028 | 0.79 | KDM4E (0.46) | KMT2AMEN1BLMKDM4EHTT | |
| SCHEMBL24233017 | 0.78 | CDK5 (0.67) | KMT2AMEN1BLMKDM4EHTT | |
| SCHEMBL24233120 | 0.78 | BLM (0.59) | KMT2AMEN1BLMKDM4EHTT | |
| SCHEMBL24232775 | 0.77 | KMT2A (0.69) | KMT2AMEN1BLMKDM4EHTT | |
| SCHEMBL24232996 | 0.77 | MCL1 (0.70) | KMT2AMEN1BLMKDM4EHTT | |
| SCHEMBL24233034 | 0.76 | KDM4E (0.57) | KMT2AMEN1BLMKDM4EHTT | |
| SCHEMBL24233015 | 0.75 | BLM (0.77) | KMT2AMEN1BLMKDM4EHTT | |
| SCHEMBL18292328 | 0.73 | MAPK8 (0.72) | KMT2AMEN1BLMKDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022026823-A1 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CHAN ZUCKERBERG BIOHUB, INC. (US) | 2022-02-03 | — | — | WO | disclosed |