Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 14/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.59 |
| ▸ | MCL1 | Q07820 | 5/20 | 0.59 |
| ▸ | HTT | P42858 | 5/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | POLB | P06746 | 3/20 | 0.59 |
| ▸ | WRN | Q14191 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.59 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.59 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.59 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24233034 | 0.85 | KDM4E (0.57) | BLMKDM4EMCL1HTTKMT2A | |
| SCHEMBL24232994 | 0.84 | BLM (0.61) | BLMKDM4EMCL1HTTKMT2A | |
| SCHEMBL24232866 | 0.82 | KMT2A (0.75) | BLMKDM4EMCL1HTTKMT2A | |
| SCHEMBL24232996 | 0.80 | MCL1 (0.70) | BLMKDM4EMCL1HTTKMT2A | |
| SCHEMBL24232825 | 0.78 | BLM (0.76) | BLMKDM4EMCL1HTTKMT2A | |
| SCHEMBL24232995 | 0.78 | KMT2A (0.56) | BLMKDM4EMCL1HTTKMT2A | |
| SCHEMBL24233006 | 0.77 | KMT2A (0.58) | BLMKDM4EMCL1HTTKMT2A | |
| SCHEMBL20548599 | 0.75 | MEN1 (0.55) | BLMKDM4EMCL1HTTKMT2A | |
| SCHEMBL24232779 | 0.74 | KMT2A (0.79) | BLMKDM4EMCL1HTTKMT2A | |
| SCHEMBL24233015 | 0.73 | BLM (0.77) | BLMKDM4EMCL1HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022026823-A1 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CHAN ZUCKERBERG BIOHUB, INC. (US) | 2022-02-03 | — | — | WO | disclosed |