Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 5/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | SNCA | P37840 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALB | P02768 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | RARB | P10826 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17049798 | 0.85 | GABRA1 (0.42) | GABRA1GABRB2RORCS1PR1CTSS | |
| SCHEMBL11020423 | 0.83 | CYP2A6 (0.48) | RORCCYP2A6PDE3BPDE3ASNCA | |
| SCHEMBL28750175 | 0.82 | MAOB (0.50) | GABRA1GABRB2CTSSCTSK | |
| SCHEMBL23572121 | 0.81 | CYP2A6 (0.45) | RORCCYP2A6ALOX5APESR1 | |
| SCHEMBL16956873 | 0.79 | SNCA (0.41) | RORCCYP2A6PDE3BPDE3ASNCA | |
| SCHEMBL13349364 | 0.77 | GABRA1 (0.58) | GABRA1GABRB2PDE3ASNCAPTGS2 | |
| SCHEMBL2418344 | 0.77 | TSHR (0.47) | GABRA1GABRB2CTSSCTSKALOX5AP | |
| SCHEMBL24232843 | 0.77 | GABRA1 (0.41) | GABRA1GABRB2CTSSCTSKALOX5AP | |
| SCHEMBL22664390 | 0.77 | GABRA1 (0.41) | GABRA1GABRB2CTSSCTSKALOX5AP | |
| SCHEMBL3162201 | 0.77 | GABRA1 (0.41) | GABRA1GABRB2CTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022026823-A1 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CHAN ZUCKERBERG BIOHUB, INC. (US) | 2022-02-03 | — | — | WO | disclosed |