Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE8B | O95263 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 11/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 10/20 | 0.41 |
| ▸ | PI4KA | P42356 | 5/20 | 0.41 |
| ▸ | PI4K2B | Q8TCG2 | 5/20 | 0.41 |
| ▸ | PI4K2A | Q9BTU6 | 5/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 5/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 6/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | AHCY | P23526 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21759036 | 0.84 | PDE8B (0.46) | PDE8BADORA2AADORA1PI4KAPI4K2B | |
| SCHEMBL13851102 | 0.81 | ADORA2A (0.53) | PDE8BADORA2AADORA1PI4KAPI4K2B | |
| SCHEMBL21504439 | 0.80 | PDE8B (0.52) | PDE8BADORA2AADORA1PI4KAPI4K2B | |
| SCHEMBL7104678 | 0.75 | ADORA2A (0.52) | PDE8BADORA2AADORA1PI4KAPI4K2B | |
| SCHEMBL21942687 | 0.75 | ADORA2A (0.44) | PDE8BADORA2AADORA1PI4KAPI4K2B | |
| SCHEMBL14201625 | 0.73 | ADORA2A (0.57) | PDE8BADORA2AADORA1ADORA2BADORA3 | |
| SCHEMBL25811783 | 0.72 | ADORA2A (0.68) | ADORA2AADORA1PI4KAPI4K2BPI4K2A | |
| SCHEMBL763189 | 0.72 | ADORA2A (0.53) | ADORA2AADORA1PI4KAPI4K2BPI4K2A | |
| SCHEMBL8357826 | 0.71 | ADORA2A (0.59) | PDE8BADORA2AADORA1ADORA2BAHCY | |
| SCHEMBL8357822 | 0.71 | ADORA2A (0.59) | PDE8BADORA2AADORA1ADORA2BAHCY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220033431-A1 | Cyclic Di-Nucleotide Compounds as STING Agonists | MERCK SHARP & DOHME CORP. (US) | 2022-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220033431-A1 | Cyclic Di-Nucleotide Compounds as STING Agonists | STING1, CGAS, IFNAR1 | PDE8B 134/4885ADORA2A 64/4885ADORA1 32/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.