Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 6/20 | 0.42 |
| ▸ | EML4 | Q9HC35 | 5/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | MLNR | O43193 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | NQO2 | P16083 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22509245 | 0.90 | EGFR (0.48) | EGFRPTK2KCNH2 | |
| SCHEMBL22509168 | 0.85 | PTK2 (0.51) | EGFRPTK2ALKEML4KCNH2 | |
| SCHEMBL19336965 | 0.84 | EGFR (0.48) | EGFRALKEML4KCNH2MLNR | |
| SCHEMBL22509271 | 0.83 | PTK2 (0.48) | PTK2ALKINSRKDRJAK3 | |
| SCHEMBL22415729 | 0.82 | EGFR (0.65) | EGFRALKEML4KCNH2MLNR | |
| SCHEMBL19337022 | 0.81 | EGFR (0.47) | EGFRALKEML4KCNH2MLNR | |
| SCHEMBL30041502 | 0.80 | EGFR (0.51) | EGFRALKEML4KCNH2 | |
| SCHEMBL24663099 | 0.79 | EGFR (0.41) | EGFRALKEML4KCNH2ERBB3 | |
| SCHEMBL26324498 | 0.79 | EGFR (0.51) | EGFRALKEML4 | |
| SCHEMBL19337153 | 0.78 | EGFR (0.50) | EGFRALKEML4KCNH2MLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3950686-A1 | N-HETEROAROMATIC AMIDE DERIVATIVES FOR TREATMENT OF CANCER | Shenzhen Forward Pharmaceuticals Co., Ltd. (CN) | 2022-02-09 | — | — | EP | disclosed |