Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MDM2 | Q00987 | 6/20 | 0.50 |
| ▸ | TLR2 | O60603 | 3/20 | 0.49 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.49 |
| ▸ | KLK7 | P49862 | 1/20 | 0.43 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MDM4 | O15151 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29812585 | 0.98 | KMT2A (0.53) | KMT2AMDM2TLR2TLR1KLK7 | |
| SCHEMBL16870063 | 0.98 | KMT2A (0.53) | KMT2AMDM2TLR2TLR1KLK7 | |
| SCHEMBL29768865 | 0.98 | KMT2A (0.53) | KMT2AMDM2TLR2TLR1KLK7 | |
| SCHEMBL24246257 | 0.98 | KMT2A (0.53) | KMT2AMDM2TLR2TLR1KLK7 | |
| SCHEMBL1738182 | 0.90 | MDM2 (0.59) | KMT2AMDM2TLR2TLR1ALDH1A1 | |
| SCHEMBL30886226 | 0.90 | MDM2 (0.59) | KMT2AMDM2TLR2TLR1ALDH1A1 | |
| SCHEMBL29370147 | 0.90 | MDM2 (0.59) | KMT2AMDM2TLR2TLR1ALDH1A1 | |
| SCHEMBL2524769 | 0.90 | MDM2 (0.59) | KMT2AMDM2TLR2TLR1ALDH1A1 | |
| SCHEMBL2292778 | 0.90 | MDM2 (0.59) | KMT2AMDM2TLR2TLR1ALDH1A1 | |
| SCHEMBL29372236 | 0.90 | MDM2 (0.59) | KMT2AMDM2TLR2TLR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3086815-B1 | SULFONAMIDE-CONTAINING LINKAGE SYSTEMS FOR DRUG CONJUGATES | ZYMEWORKS INC (CA) | 2022-02-09 | — | — | EP | disclosed |