Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 20/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19149924 | 0.91 | ROCK2 (0.71) | ROCK2 | |
| SCHEMBL19128500 | 0.90 | ROCK2 (0.77) | ROCK2 | |
| SCHEMBL19127971 | 0.88 | ROCK2 (0.74) | ROCK2 | |
| SCHEMBL20647064 | 0.86 | ROCK2 (0.74) | ROCK2 | |
| SCHEMBL19151010 | 0.86 | ROCK2 (0.69) | ROCK2 | |
| Formamide SCHEMBL20638682 | 0.85 | ROCK2 (0.70) | ROCK2 | |
| SCHEMBL19128283 | 0.85 | ROCK2 (0.74) | ROCK2 | |
| SCHEMBL23382599 | 0.85 | ROCK2 (1.00) | ROCK2 | |
| SCHEMBL19127334 | 0.84 | ROCK2 (0.64) | ROCK2 | |
| SCHEMBL23889153 | 0.84 | ROCK2 (0.68) | ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3954681-A1 | SPIROHEPTANE SALICYLAMIDES AND RELATED COMPOUNDS AS INHIBITORS OF ROCK | Bristol-Myers Squibb Company (US) | 2022-02-16 | — | — | EP | disclosed |