Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 20/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20646756 | 0.86 | ROCK2 (0.62) | ROCK2 | |
| SCHEMBL19127200 | 0.83 | ROCK2 (0.74) | ROCK2 | |
| SCHEMBL19151443 | 0.82 | ROCK2 (0.61) | ROCK2 | |
| SCHEMBL23587195 | 0.79 | ROCK2 (0.58) | ROCK2 | |
| SCHEMBL20646924 | 0.79 | ROCK2 (0.62) | ROCK2 | |
| SCHEMBL19150903 | 0.78 | ROCK2 (0.65) | ROCK2 | |
| SCHEMBL19128499 | 0.77 | ROCK2 (0.74) | ROCK2 | |
| SCHEMBL19150730 | 0.76 | ROCK2 (0.79) | ROCK2 | |
| SCHEMBL17454370 | 0.75 | ROCK2 (0.55) | ROCK2 | |
| SCHEMBL23587398 | 0.75 | ROCK2 (0.53) | ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3954681-A1 | SPIROHEPTANE SALICYLAMIDES AND RELATED COMPOUNDS AS INHIBITORS OF ROCK | Bristol-Myers Squibb Company (US) | 2022-02-16 | — | — | EP | disclosed |