Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 6/20 | 0.46 |
| ▸ | JAK1 | P23458 | 6/20 | 0.46 |
| ▸ | TYK2 | P29597 | 6/20 | 0.46 |
| ▸ | JAK3 | P52333 | 5/20 | 0.46 |
| ▸ | RET | P07949 | 12/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21872437 | 0.72 | JAK1 (0.62) | JAK2JAK1TYK2JAK3RET | |
| SCHEMBL24567411 | 0.72 | JAK2 (0.49) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL22549352 | 0.70 | JAK2 (0.67) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL22549482 | 0.70 | JAK2 (0.46) | JAK2JAK1TYK2JAK3RET | |
| SCHEMBL24248071 | 0.70 | JAK2 (0.67) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL24248078 | 0.69 | JAK2 (0.64) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL22549479 | 0.69 | JAK2 (0.64) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL22449704 | 0.67 | JAK1 (0.66) | JAK2JAK1TYK2JAK3CLK2 | |
| SCHEMBL19299994 | 0.66 | JAK1 (0.94) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL22549332 | 0.66 | JAK1 (0.59) | JAK2JAK1TYK2JAK3CLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3954689-A1 | PYRAZOLOPYRAZINE DERIVED COMPOUNDS, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Primegene (Beijing) Co., Ltd. (CN) | 2022-02-16 | — | — | EP | disclosed |