Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 8/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 2/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24250212 | 0.85 | IRAK4 (0.44) | IRAK4 | |
| SCHEMBL19957325 | 0.82 | ALDH1A1 (0.52) | PDGFRBPDGFRASRCTGFBR1FGFR2 | |
| SCHEMBL24250076 | 0.80 | IRAK4 (0.68) | IRAK4 | |
| SCHEMBL24250205 | 0.80 | IRAK4 (0.70) | IRAK4 | |
| SCHEMBL24250079 | 0.80 | IRAK4 (0.68) | IRAK4 | |
| SCHEMBL24250089 | 0.80 | SRC (0.50) | IRAK4PDGFRBPDGFRASRCTGFBR1 | |
| SCHEMBL18573759 | 0.78 | IRAK4 (0.42) | IRAK4 | |
| SCHEMBL24250074 | 0.78 | IRAK4 (0.71) | IRAK4 | |
| SCHEMBL22959985 | 0.77 | SRC (0.47) | PDGFRBPDGFRASRC | |
| SCHEMBL24249981 | 0.77 | IRAK4 (0.70) | IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3536685-B1 | BICYCLIC-FUSED HETEROARYL OR ARYL COMPOUNDS AND THEIR USE AS IRAK4 INHIBITORS | PFIZER (US) | 2022-02-16 | — | — | EP | disclosed |