Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 9/20 | 0.46 |
| ▸ | EGFR | P00533 | 3/20 | 0.45 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.43 |
| ▸ | JAK3 | P52333 | 6/20 | 0.42 |
| ▸ | JAK2 | O60674 | 5/20 | 0.42 |
| ▸ | JAK1 | P23458 | 3/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22132768 | 0.88 | EGFR (0.45) | BTKEGFRFGFR4FGFR1JAK3 | |
| SCHEMBL30515900 | 0.82 | FGFR1 (0.49) | BTKFGFR4FGFR1 | |
| SCHEMBL22186345 | 0.81 | RIPK1 (0.49) | EGFRCSNK2A2CSNK2A1 | |
| SCHEMBL22132866 | 0.81 | RIPK1 (0.49) | EGFRCSNK2A2CSNK2A1 | |
| SCHEMBL23337029 | 0.80 | FGFR4 (0.60) | BTKFGFR4FGFR1 | |
| SCHEMBL23337047 | 0.80 | FGFR4 (0.60) | BTKFGFR4FGFR1 | |
| SCHEMBL23337058 | 0.80 | FGFR4 (0.60) | BTKFGFR4FGFR1 | |
| SCHEMBL29063774 | 0.80 | FGFR4 (0.51) | BTKFGFR4FGFR1 | |
| SCHEMBL22132909 | 0.78 | FGFR1 (0.63) | FGFR4FGFR1 | |
| SCHEMBL22132910 | 0.78 | FGFR1 (0.63) | FGFR4FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3670513-B1 | FGFR INHIBITOR AND MEDICAL APPLICATION THEREOF | CSPC ZHONGQI PHARMACEUTICAL TECH SHIJIAZHUANG CO LTD (CN) | 2023-09-20 | — | — | EP | disclosed |
| EP-4169922-A1 | FGFR AND MUTATION INHIBITOR THEREOF, AND PREPARATION METHOD THEREFOR AND USE THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2023-04-26 | — | — | EP | disclosed |
| WO-2022033532-A1 | FGFR AND MUTATION INHIBITOR THEREOF, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 上海和誉生物医药科技有限公司 | 2022-02-17 | — | — | WO | disclosed |