Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.33 |
| ▸ | PARP11 | Q9NR21 | 3/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | TAF1 | P21675 | 1/20 | 0.32 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.32 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.32 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | TNF | P01375 | 1/20 | 0.30 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.30 |
| ▸ | PTPRC | P08575 | 1/20 | 0.30 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.30 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.30 |
| ▸ | PTPRB | P23467 | 1/20 | 0.30 |
| ▸ | PTPRE | P23469 | 1/20 | 0.30 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2424580 | 0.70 | MAP2K1 (0.41) | PARP10PARP11MAP2K1PDPK1 | |
| SCHEMBL2421974 | 0.69 | PARP10 (0.40) | PARP10PARP11 | |
| SCHEMBL25400074 | 0.68 | TNF (0.33) | PDPK1TNFRIPK1 | |
| SCHEMBL2425515 | 0.66 | MAPT (0.43) | — | |
| SCHEMBL2421514 | 0.65 | MAP2K1 (0.42) | MAP2K1 | |
| SCHEMBL794250 | 0.61 | PARP11 (0.44) | PARP10PARP11PDPK1 | |
| SCHEMBL8592676 | 0.61 | PARP1 (0.53) | BRD4TAF1BRPF1CREBBPCECR2 | |
| SCHEMBL1374474 | 0.60 | TNF (0.54) | BRD4TAF1BRPF1CREBBPCECR2 | |
| SCHEMBL29591462 | 0.60 | TNF (0.54) | BRD4TAF1BRPF1CREBBPCECR2 | |
| SCHEMBL8689309 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1540329-A4 | DRUG DISCOVERY METHOD | KEDDEM BIO SCIENCE LTD (IL) | 2009-06-10 | — | — | EP | claimed |
| JP-2006507480-A | — | — | 2006-03-02 | — | — | JP | claimed |
| EP-1540329-A1 | DRUG DISCOVERY METHOD | KEDDEM BIO-SCIENCE LTD. (IL) | 2005-06-15 | — | — | EP | claimed |
| WO-2004010136-A1 | DRUG DISCOVERY METHOD | KEDDEM BIO-SCIENCE LTD. (IL) | 2004-01-29 | — | — | WO | claimed |
| US-20160314241-A1 | DRUG DISCOVERY METHOD | Keddem Bioscience Ltd. (IL) | 2016-10-27 | — | — | US | disclosed |
| US-20160314241-A1 | DRUG DISCOVERY METHOD | Keddem Bioscience Ltd. (IL) | 2016-10-27 | — | — | US | disclosed |
| US-20160314241-A1 | DRUG DISCOVERY METHOD | Keddem Bioscience Ltd. (IL) | 2016-10-27 | — | — | US | disclosed |
| US-9405885-B2 | Drug discovery method | Keddem Bioscience Ltd. (IL) | 2016-08-02 | — | — | US | disclosed |
| US-9405885-B2 | Drug discovery method | Keddem Bioscience Ltd. (IL) | 2016-08-02 | — | — | US | disclosed |
| US-9405885-B2 | Drug discovery method | Keddem Bioscience Ltd. (IL) | 2016-08-02 | — | — | US | disclosed |
| EP-2581849-A1 | Drug discovery method | KEDDEM BIO-SCIENCE LTD. (IL) | 2013-04-17 | — | — | EP | disclosed |
| EP-2581849-A1 | Drug discovery method | KEDDEM BIO-SCIENCE LTD. (IL) | 2013-04-17 | — | — | EP | disclosed |
| US-20110237458-A1 | DRUG DISCOVERY METHOD | Keddem Bioscience Ltd. (IL) | 2011-09-29 | — | — | US | disclosed |
| US-8019550-B2 | Drug discovery method | Keddem Bioscience Ltd. (IL) | 2011-09-13 | — | — | US | disclosed |
| US-8019550-B2 | Drug discovery method | Keddem Bioscience Ltd. (IL) | 2011-09-13 | — | — | US | disclosed |
| US-8019550-B2 | Drug discovery method | Keddem Bioscience Ltd. (IL) | 2011-09-13 | — | — | US | disclosed |
| EP-1540329-A4 | DRUG DISCOVERY METHOD | KEDDEM BIO SCIENCE LTD (IL) | 2009-06-10 | — | — | EP | disclosed |
| US-20050277117-A1 | Drug discovery method | KEDDEM BIO-SCIENCE LTD. (IL) | 2005-12-15 | — | — | US | disclosed |
| EP-1540329-A1 | DRUG DISCOVERY METHOD | KEDDEM BIO-SCIENCE LTD. (IL) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004010136-A1 | DRUG DISCOVERY METHOD | KEDDEM BIO-SCIENCE LTD. (IL) | 2004-01-29 | — | — | WO | disclosed |