Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F12 | P00748 | 4/20 | 0.60 |
| ▸ | PLG | P00747 | 2/20 | 0.60 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.60 |
| ▸ | F11 | P03951 | 1/20 | 0.60 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.60 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.60 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.60 |
| ▸ | DHFR | P00374 | 4/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.43 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.39 |
| ▸ | TARS1 | P26639 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ADK | P55263 | 1/20 | 0.36 |
| ▸ | KLK1 | P06870 | 1/20 | 0.36 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30451495 | 0.84 | DHFR (0.46) | F12PLGKLKB1F11PRSS1 | |
| SCHEMBL24252675 | 0.84 | DHFR (0.46) | F12PLGKLKB1F11PRSS1 | |
| SCHEMBL24252653 | 0.83 | F12 (0.51) | F12PLGKLKB1F11PRSS1 | |
| SCHEMBL24252259 | 0.83 | DHFR (0.42) | F12PLGKLKB1F11PRSS1 | |
| SCHEMBL24252635 | 0.82 | DHFR (0.43) | F12PLGKLKB1F11PRSS1 | |
| SCHEMBL24252743 | 0.82 | PLG (0.41) | F12PLGKLKB1F11PRSS1 | |
| SCHEMBL24252640 | 0.81 | MAP4K4 (0.41) | F12PLGKLKB1F11PRSS1 | |
| SCHEMBL30452066 | 0.81 | MAP4K4 (0.41) | F12PLGKLKB1F11PRSS1 | |
| SCHEMBL24252651 | 0.80 | MAP4K4 (0.44) | F12PLGKLKB1F11PRSS1 | |
| Formic Acid SCHEMBL25257239 | 0.79 | DHFR (0.39) | F12PLGKLKB1F11PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220048930-A1 | INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF | ANNEXON, INC. | 2022-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220048930-A1 | INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF | CFB, CFH, C9 | F12 29/4885PLG 260/4885KLKB1 481/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.