Sugi Predict

Sugi Predict / Compounds / SCHEMBL24252962

SCHEMBL24252962

SCHEMBL24252962

COc1ccc(CNc2cnnc3cc(-c4cc(B5OC(C)(C)C(C)(C)O5)ccc4NC(=O)CCC(C)C)ccc23)c(OC)c1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4C Q9H3R0 1/20 0.35
▸ ALDH1A1 P00352 6/20 0.34
▸ ROCK2 O75116 1/20 0.33
▸ CYP1A2 P05177 7/20 0.33
▸ CYP3A4 P08684 7/20 0.33
▸ CYP2C19 P33261 7/20 0.33
▸ HSD17B10 Q99714 5/20 0.33
▸ CYP2D6 P10635 5/20 0.33
▸ CYP2C9 P11712 4/20 0.33
▸ MAPK1 P28482 4/20 0.33
▸ CLK4 Q9HAZ1 4/20 0.33
▸ TSHR P16473 3/20 0.33
▸ LMNA P02545 3/20 0.33
▸ PDE10A Q9Y233 1/20 0.33
▸ CSF1R P07333 2/20 0.33
▸ PDGFRB P09619 2/20 0.33
▸ PDE9A O76083 2/20 0.33
▸ KDR P35968 1/20 0.33
▸ HIF1A Q16665 2/20 0.33
▸ KDM4E B2RXH2 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30467605 1.00 KDM4C (0.35) KDM4CALDH1A1ROCK2CYP1A2CYP3A4
SCHEMBL24252881 0.93 KDM4C (0.36) KDM4CALDH1A1ROCK2CYP1A2CYP3A4
SCHEMBL30467644 0.93 KDM4C (0.36) KDM4CALDH1A1ROCK2CYP1A2CYP3A4
SCHEMBL30467732 0.85 CYP1A2 (0.36) ALDH1A1ROCK2CYP1A2CYP3A4CYP2C19
SCHEMBL24252367 0.85 CYP1A2 (0.36) ALDH1A1ROCK2CYP1A2CYP3A4CYP2C19
SCHEMBL24252831 0.85 CYP1A2 (0.38) KDM4CALDH1A1CYP1A2CYP3A4CYP2C19
SCHEMBL30467795 0.85 CYP1A2 (0.38) KDM4CALDH1A1CYP1A2CYP3A4CYP2C19
SCHEMBL24252791 0.85 CYP1A2 (0.41) KDM4CALDH1A1CYP1A2CYP3A4CYP2C19
SCHEMBL30467683 0.85 CYP1A2 (0.41) KDM4CALDH1A1CYP1A2CYP3A4CYP2C19
SCHEMBL24252969 0.82 KDM4C (0.41) KDM4CALDH1A1CYP1A2CYP3A4CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260070932-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF ANNEXON INC (US) 2026-03-12 — — US disclosed
US-12509474-B2 Inhibitors of complement factors and uses thereof ANNEXON, INC. (US) 2025-12-30 — — US disclosed
US-20240109920-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF ANNEXON, INC. 2024-04-04 — — US disclosed
US-11814404-B2 Inhibitors of complement factors and uses thereof ANNEXON, INC. (US) 2023-11-14 — — US disclosed
US-11814404-B2 Inhibitors of complement factors and uses thereof ANNEXON, INC. (US) 2023-11-14 — — US disclosed
US-11814404-B2 Inhibitors of complement factors and uses thereof ANNEXON, INC. (US) 2023-11-14 — — US disclosed
CN-116947903-A Inhibitors of complement factors and uses thereof 安尼艾克松股份有限公司 2023-10-27 — — CN disclosed
CN-116261564-A Inhibitors of complement factors and uses thereof 安尼艾克松股份有限公司 2023-06-13 — — CN disclosed
EP-4185592-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF Annexon, Inc. (US) 2023-05-31 — — EP disclosed
US-20220048930-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF ANNEXON, INC. 2022-02-17 — — US disclosed
US-20220048930-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF ANNEXON, INC. 2022-02-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240109920-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF CFB, CFH, C9 KDM4C 4542/4885ALDH1A1 653/4885ROCK2 3538/4885
US-20220048930-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF CFB, CFH, C9 KDM4C 4542/4885ALDH1A1 653/4885ROCK2 3538/4885
US-11814404-B2 Inhibitors of complement factors and uses thereof CFB, CFH, C9 KDM4C 4542/4885ALDH1A1 653/4885ROCK2 3538/4885
US-12509474-B2 Inhibitors of complement factors and uses thereof SSB, UACA, CFH KDM4C 3892/4885ALDH1A1 3178/4885ROCK2 4227/4885
US-20260070932-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF CFH, CFB, C5 KDM4C 4654/4885ALDH1A1 3094/4885ROCK2 4278/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.