Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | DTYMK | P23919 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | CASR | P41180 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2845642 | 0.79 | MCL1 (0.67) | MCL1ALDH1A1DTYMKKDM4EHPGD | |
| SCHEMBL24138307 | 0.75 | MCL1 (0.43) | MCL1ALDH1A1DTYMKKDM4EHPGD | |
| SCHEMBL16203373 | 0.74 | MCL1 (0.64) | MCL1ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL18211376 | 0.72 | DTYMK (0.45) | MCL1ALDH1A1DTYMKKDM4EHPGD | |
| SCHEMBL13861288 | 0.72 | MCL1 (0.41) | MCL1ALDH1A1DTYMKKDM4EHPGD | |
| SCHEMBL11111985 | 0.72 | SLC16A3 (0.49) | MCL1ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL223101 | 0.70 | CSNK2A1 (0.65) | MCL1ALDH1A1KDM4EHPGDCSNK2A1 | |
| SCHEMBL70164 | 0.70 | MCL1 (0.66) | MCL1ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL24254574 | 0.69 | HPGD (0.51) | ALDH1A1HPGDTSHRMEN1KMT2A | |
| SCHEMBL20826224 | 0.69 | HSD17B10 (0.63) | ALDH1A1KDM4EHPGDHSD17B10POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022035804-A1 | SUBSTITUTED 3-AMINO-4-METHYLBENZENESULFONAMIDES AS SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-02-17 | — | — | WO | disclosed |