Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 4/20 | 0.42 |
| ▸ | CNR2 | P34972 | 3/20 | 0.42 |
| ▸ | WDR5 | P61964 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24254576 | 0.85 | KMT2A (0.51) | APEX1MEN1KMT2A | |
| SCHEMBL24254492 | 0.78 | NPC1 (0.61) | HPGDLMNATSHRAPEX1SMN1; SMN2 | |
| SCHEMBL26188116 | 0.75 | EPHX2 (0.61) | HPGDLMNAAPEX1ALDH1A1MEN1 | |
| SCHEMBL24254575 | 0.74 | MAPT (0.53) | LMNASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL6358333 | 0.70 | HPGD (0.62) | HPGDLMNATSHRAPEX1SMN1; SMN2 | |
| SCHEMBL11776286 | 0.70 | TSHR (0.66) | HPGDLMNATSHRAPEX1SMN1; SMN2 | |
| SCHEMBL2980187 | 0.69 | LMNA (0.62) | HPGDLMNATSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL24254520 | 0.69 | MCL1 (0.43) | HPGDTSHRALDH1A1MEN1KMT2A | |
| SCHEMBL7616443 | 0.69 | LMNA (0.65) | HPGDLMNATSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL3169688 | 0.69 | TSHR (0.69) | HPGDLMNATSHRAPEX1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022035804-A1 | SUBSTITUTED 3-AMINO-4-METHYLBENZENESULFONAMIDES AS SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-02-17 | — | — | WO | disclosed |