Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24254555 | 0.81 | MAPK1 (0.38) | TSHRMAPK1MAPTPOLBRAB9A | |
| SCHEMBL24254515 | 0.76 | MAPT (0.48) | MAPTPOLBGAAALDH1A1KMT2A | |
| SCHEMBL9352526 | 0.76 | ALDH1A1 (0.47) | TSHRMAPK1MAPTPOLBRAB9A | |
| SCHEMBL24254518 | 0.73 | ALDH1A1 (0.49) | TSHRPOLBALDH1A1NPSR1KMT2A | |
| SCHEMBL23524965 | 0.72 | KDM4E (0.56) | TSHRMAPTPOLBRAB9AGAA | |
| SCHEMBL24254513 | 0.72 | ALDH1A1 (0.56) | MAPTRAB9ANPC1GAAALDH1A1 | |
| SCHEMBL18409424 | 0.70 | KMT2A (0.43) | MAPK1MAPTPOLBRAB9ANPC1 | |
| SCHEMBL12329332 | 0.70 | HTT (0.52) | TSHRMAPK1MAPTGAAALDH1A1 | |
| SCHEMBL12594066 | 0.69 | ALDH1A1 (0.49) | MAPTPOLBRAB9ANPC1GAA | |
| SCHEMBL14204703 | 0.69 | ALDH1A1 (0.40) | TSHRMAPK1MAPTPOLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022035804-A1 | SUBSTITUTED 3-AMINO-4-METHYLBENZENESULFONAMIDES AS SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-02-17 | — | — | WO | disclosed |