Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 17/20 | 0.64 |
| ▸ | INSR | P06213 | 2/20 | 0.64 |
| ▸ | JAK2 | O60674 | 3/20 | 0.63 |
| ▸ | SRC | P12931 | 3/20 | 0.63 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.63 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.62 |
| ▸ | IGF1R | P08069 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24255305 | 0.92 | ALK (0.73) | ALKINSRJAK2SRCTNK2 | |
| SCHEMBL24255315 | 0.92 | ALK (0.67) | ALKINSRJAK2SRCTNK2 | |
| SCHEMBL24255322 | 0.86 | LRRK2 (0.58) | ALKINSRJAK2SRCTNK2 | |
| SCHEMBL24255323 | 0.84 | ALK (0.57) | ALKINSRJAK2SRCTNK2 | |
| SCHEMBL24255302 | 0.84 | ALK (0.77) | ALKINSRJAK2SRCTNK2 | |
| SCHEMBL24255317 | 0.84 | TNK2 (0.60) | ALKJAK2SRCTNK2LRRK2 | |
| SCHEMBL24255248 | 0.83 | JAK3 (0.64) | ALKINSRJAK2SRCTNK2 | |
| SCHEMBL24258128 | 0.83 | ALK (0.57) | ALKINSRJAK2SRCTNK2 | |
| SCHEMBL24255249 | 0.82 | JAK3 (0.64) | ALKINSRJAK2SRCTNK2 | |
| SCHEMBL24255508 | 0.80 | ALK (0.64) | ALKINSRJAK2SRCTNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022036312-A2 | INHIBITORS OF ACK1/TNK1 TYROSINE KINASE | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2022-02-17 | — | — | WO | disclosed |