Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 7/20 | 0.58 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.55 |
| ▸ | INSR | P06213 | 2/20 | 0.55 |
| ▸ | IGF1R | P08069 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 8/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | SRC | P12931 | 1/20 | 0.53 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.53 |
| ▸ | MET | P08581 | 1/20 | 0.48 |
| ▸ | TTK | P33981 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24255320 | 0.93 | LRRK2 (0.63) | LRRK2ALKINSRIGF1REGFR | |
| SCHEMBL24255508 | 0.92 | ALK (0.64) | LRRK2ALKINSRIGF1REGFR | |
| SCHEMBL24255319 | 0.86 | ALK (0.64) | LRRK2ALKINSRIGF1RJAK2 | |
| SCHEMBL24255507 | 0.85 | LRRK2 (0.64) | LRRK2ALKINSRIGF1REGFR | |
| SCHEMBL24255313 | 0.84 | TNK2 (0.57) | LRRK2ALKJAK2SRCTNK2 | |
| SCHEMBL24255305 | 0.80 | ALK (0.73) | LRRK2ALKINSRIGF1REGFR | |
| SCHEMBL24255315 | 0.80 | ALK (0.67) | LRRK2ALKINSRIGF1REGFR | |
| SCHEMBL24255227 | 0.78 | LRRK2 (0.55) | LRRK2ALKINSRIGF1REGFR | |
| SCHEMBL17644522 | 0.77 | LRRK2 (0.63) | LRRK2ALKINSRIGF1REGFR | |
| SCHEMBL26270103 | 0.77 | TNK2 (0.58) | ALKJAK2SRCTNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022036312-A2 | INHIBITORS OF ACK1/TNK1 TYROSINE KINASE | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2022-02-17 | — | — | WO | disclosed |