Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 3/20 | 0.44 |
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.44 |
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.44 |
| ▸ | CHRM4 known ✓ | P08173 | 1/20 | 0.44 |
| ▸ | CHRM5 known ✓ | P08912 | 1/20 | 0.44 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.44 |
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.42 |
| ▸ | KDM4A | O75164 | 2/20 | 0.56 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.50 |
| ▸ | NPC1 | O15118 | 6/20 | 0.50 |
| ▸ | RAB9A | P51151 | 6/20 | 0.50 |
| ▸ | HTT | P42858 | 6/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | RAD52 | P43351 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL28214927 | 1.00 | KDM4A (0.56) | KDM4AKDM2ASMN1; SMN2NPC1RAB9A | |
| Bromide SCHEMBL28803406 | 1.00 | KDM4A (0.56) | KDM4AKDM2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL19582519 | 0.98 | KDM4A (0.57) | KDM4AKDM2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL29431056 | 0.98 | KDM4A (0.57) | KDM4AKDM2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL19582692 | 0.98 | KDM4A (0.57) | KDM4AKDM2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL19582767 | 0.98 | KDM4A (0.57) | KDM4AKDM2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL4370196 | 0.98 | KDM4A (0.57) | KDM4AKDM2ASMN1; SMN2NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL8941741 | 0.97 | KDM4A (0.56) | KDM4AKDM2ASMN1; SMN2NPC1RAB9A | |
| Iodide SCHEMBL10938526 | 0.97 | KDM4A (0.58) | KDM4AKDM2ASMN1; SMN2NPC1RAB9A | |
| Iodide SCHEMBL10938556 | 0.97 | KDM4A (0.58) | KDM4AKDM2ASMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10331054-B2 | Electrophotographic member, process cartridge and electrophotographic image forming apparatus | CANON KABUSHIKI KAISHA (JP) | 2019-06-25 | — | — | US | disclosed |
| US-20170329251-A1 | ELECTROPHOTOGRAPHIC MEMBER, PROCESS CARTRIDGE AND ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS | CANON KABUSHIKI KAISHA (JP) | 2017-11-16 | — | — | US | disclosed |
| US-20110229930-A1 | MICROORGANISM COMPRISING PARTICLES AND USES OF SAME | MENASHE OFIR | 2011-09-22 | — | — | US | disclosed |
| US-7151139-B2 | Antimicrobial polymeric surfaces | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2006-12-19 | — | — | US | disclosed |
| US-20050249695-A1 | Antimicrobial polymeric surfaces | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2005-11-10 | — | — | US | disclosed |
| EP-1390158-A4 | ANTIMICROBIAL POLYMERIC SURFACES | MASSACHUSETTS INST TECHNOLOGY (US) | 2004-06-09 | — | — | EP | disclosed |
| EP-1390158-A1 | ANTIMICROBIAL POLYMERIC SURFACES | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2004-02-25 | — | — | EP | disclosed |
| US-20030091641-A1 | Antimicrobial polymeric surfaces | TRUSTEES OF TUFTS COLLEGE | 2003-05-15 | — | — | US | disclosed |
| WO-2002085542-A1 | ANTIMICROBIAL POLYMERIC SURFACES | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2002-10-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030091641-A1 | Antimicrobial polymeric surfaces | PUF60, PHOSPHO1, PNKP | ACHE 945/4885CHRM2 3283/4885CHRM1 2420/4885 |
| US-20050249695-A1 | Antimicrobial polymeric surfaces | PUF60, PHOSPHO1, PNKP | ACHE 945/4885CHRM2 3283/4885CHRM1 2420/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.