Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | NSD2 | O96028 | 1/20 | 0.43 |
| ▸ | STIM1 | Q13586 | 2/20 | 0.34 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 2/20 | 0.30 |
| ▸ | MAOB | P27338 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19531676 | 0.93 | ALDH1A1 (0.43) | ALDH1A1MAPTKDM4ENSD2STIM1 | |
| SCHEMBL24163748 | 0.84 | KDM4E (0.42) | ALDH1A1MAPTKDM4ENSD2STIM1 | |
| SCHEMBL31714344 | 0.81 | MAPT (0.42) | ALDH1A1MAPTKDM4ENSD2 | |
| SCHEMBL15730121 | 0.81 | KDM4E (0.52) | ALDH1A1MAPTKDM4ENSD2STIM1 | |
| SCHEMBL29318295 | 0.79 | MAPT (0.41) | ALDH1A1MAPTKDM4ENSD2MAOA | |
| SCHEMBL29318392 | 0.79 | MAPT (0.41) | ALDH1A1MAPTKDM4ENSD2MAOA | |
| SCHEMBL29303280 | 0.78 | KDM4E (0.40) | ALDH1A1MAPTKDM4ENSD2NOTUM | |
| SCHEMBL24255256 | 0.77 | MAPT (0.42) | ALDH1A1MAPTKDM4ENSD2STIM1 | |
| SCHEMBL24930081 | 0.77 | KDM4E (0.42) | ALDH1A1MAPTKDM4ENSD2STIM1 | |
| SCHEMBL26482518 | 0.77 | MAPT (0.42) | ALDH1A1MAPTKDM4ENSD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022036177-A1 | ANTAGONISTS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY (US) | 2022-02-17 | — | — | WO | disclosed |