SCHEMBL24256618

CSCC[C@H](NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@H](C(=O)N[C@H]1CSSC[C@@H](C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CO)C(=O)N[C@H](C(N)=O)C(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC1=O)C(C)C

nearest known ligand 0.63

Predicted protein targets (top 17)

	gene	UniProt	supporting neighbours	confidence
▸	MC4R	P32245	2/20	0.63

▸	MC1R	Q01726	2/20	0.63

▸	MC3R	P41968	1/20	0.63

▸	F11	P03951	2/20	0.55

▸	KCNA3	P22001	1/20	0.55

▸	KCNA1	Q09470	1/20	0.55

▸	CXCR4	P61073	3/20	0.54

▸	NPR1	P16066	1/20	0.53

▸	NPR3	P17342	1/20	0.53

▸	KLKB1	P03952	1/20	0.53

▸	NPY2R	P49146	1/20	0.52

▸	KRAS	P01116	6/20	0.51

▸	BCL2L1	Q07817	1/20	0.51

▸	BAD	Q92934	1/20	0.51

▸	KLK7	P49862	1/20	0.51

▸	GLP1R	P43220	1/20	0.51

▸	GCGR	P47871	1/20	0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL27179393	0.98	MC4R (0.62)	MC4RMC1RMC3RF11KCNA3
SCHEMBL26899258	0.94	MC4R (0.67)	MC4RMC1RMC3RF11KCNA3
SCHEMBL24255998	0.94	MC4R (0.67)	MC4RMC1RMC3RF11KCNA3
SCHEMBL24256559	0.93	MC4R (0.61)	MC4RMC1RMC3RF11KCNA3
SCHEMBL25083695	0.91	MC4R (0.64)	MC4RMC1RMC3RF11KCNA3
SCHEMBL24932728	0.85	F11 (0.58)	MC4RMC1RMC3RF11KRAS
SCHEMBL24932671	0.85	KCNA3 (0.54)	MC4RMC1RMC3RF11KCNA3
SCHEMBL24725780	0.85	MC4R (0.61)	MC4RMC1RMC3RF11KCNA3
SCHEMBL24932558	0.84	MC4R (0.59)	MC4RMC1RMC3RF11KLKB1
SCHEMBL26880160	0.84	F11 (0.57)	MC4RMC1RMC3RF11KRAS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-20240072809-A1	ASGPR-BINDING COMPOUNDS FOR THE DEGRADATION OF EXTRACELLULAR PROTEINS	AVILAR THERAPEUTICS, INC. (US)	2024-02-29	—	—	US	disclosed
WO-2022035997-A1	IN VIVO ASSEMBLY OF ASGPR BINDING THERAPEUTICS	AVILAR THERAPEUTICS, INC. (US)	2022-02-17	—	—	WO	disclosed