Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.48 |
| ▸ | ATM | Q13315 | 4/20 | 0.48 |
| ▸ | GLA | P06280 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | CDK8 | P49336 | 1/20 | 0.48 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.44 |
| ▸ | GAA | P10253 | 7/20 | 0.44 |
| ▸ | HPGD | P15428 | 6/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24256648 | 0.79 | KDM4E (0.62) | KDM4EATMGLAL3MBTL1CDK8 | |
| SCHEMBL24256646 | 0.75 | KDM4E (0.77) | KDM4EATMGLAL3MBTL1CDK8 | |
| SCHEMBL24256384 | 0.66 | ALDH1A1 (0.48) | KDM4EATMGLAL3MBTL1CDK8 | |
| SCHEMBL24256381 | 0.66 | ALDH1A1 (0.48) | KDM4EATMGLAL3MBTL1CDK8 | |
| SCHEMBL24256851 | 0.65 | HPGD (0.74) | KDM4EL3MBTL1ALDH1A1HPGDPOLB | |
| SCHEMBL18848994 | 0.65 | CDK8 (1.00) | KDM4EATMGLAL3MBTL1CDK8 | |
| SCHEMBL18537695 | 0.64 | MAPT (0.69) | KDM4EL3MBTL1ALDH1A1GAAHPGD | |
| SCHEMBL24256903 | 0.63 | KDM4E (0.56) | KDM4EATMGLAL3MBTL1CDK8 | |
| SCHEMBL18537593 | 0.63 | KDM4E (0.57) | KDM4EATMGLAALDH1A1GAA | |
| SCHEMBL24256383 | 0.63 | ALDH1A1 (0.59) | KDM4EL3MBTL1ALDH1A1GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022035806-A1 | FUSED TRICYCLIC PYRIMIDINE-THIENO-PYRIDINE SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-02-17 | — | — | WO | disclosed |