Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 4/20 | 0.60 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 2/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24076314 | 0.87 | NLRP3 (0.65) | NLRP3PSMB1PSMB5MCL1AKR1B1 | |
| SCHEMBL24077236 | 0.85 | NLRP3 (0.62) | NLRP3PSMB1PSMB5MCL1DPP4 | |
| SCHEMBL26732673 | 0.83 | NLRP3 (0.63) | NLRP3PSMB1PSMB5MCL1 | |
| SCHEMBL30450964 | 0.83 | NLRP3 (0.63) | NLRP3PSMB1PSMB5MCL1 | |
| SCHEMBL24076245 | 0.81 | NLRP3 (0.58) | NLRP3MCL1TYRO3LMNAALDH1A1 | |
| SCHEMBL26630496 | 0.78 | NLRP3 (0.80) | NLRP3ALOX15LMNAUSP2ALDH1A1 | |
| SCHEMBL26732289 | 0.77 | NLRP3 (0.61) | NLRP3LMNAALDH1A1 | |
| SCHEMBL24257395 | 0.77 | NLRP3 (0.69) | NLRP3ALOX15LMNAUSP2ALDH1A1 | |
| SCHEMBL26630506 | 0.77 | NLRP3 (0.61) | NLRP3LMNAHPGD | |
| SCHEMBL26630501 | 0.77 | NLRP3 (0.67) | NLRP3PSMB1PSMB5ALOX15LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022036204-A1 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. (US) | 2022-02-17 | — | — | WO | disclosed |