Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 7/20 | 0.41 |
| ▸ | VEGFA | P15692 | 4/20 | 0.41 |
| ▸ | FLT1 | P17948 | 4/20 | 0.41 |
| ▸ | EGLN3 | Q9H6Z9 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | CFTR | P13569 | 2/20 | 0.37 |
| ▸ | WNT1 | P04628 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24257601 | 0.87 | EGLN1 (0.56) | EGLN1VEGFAFLT1EGLN3 | |
| SCHEMBL30546834 | 0.87 | EGLN1 (0.56) | EGLN1VEGFAFLT1EGLN3 | |
| SCHEMBL30546836 | 0.85 | EGLN1 (0.58) | EGLN1VEGFAFLT1EGLN3 | |
| SCHEMBL30452450 | 0.85 | EGLN1 (0.58) | EGLN1VEGFAFLT1EGLN3 | |
| SCHEMBL24257716 | 0.85 | EGLN1 (0.58) | EGLN1VEGFAFLT1EGLN3 | |
| SCHEMBL24257711 | 0.76 | GRM4 (0.48) | EGLN1KDM4E | |
| SCHEMBL30546862 | 0.73 | EGLN3 (0.55) | EGLN1VEGFAFLT1EGLN3 | |
| SCHEMBL24257682 | 0.73 | EGLN3 (0.55) | EGLN1VEGFAFLT1EGLN3 | |
| SCHEMBL30546813 | 0.73 | EGLN1 (0.44) | EGLN1VEGFAFLT1EGLN3HDAC6 | |
| SCHEMBL30454632 | 0.73 | EGLN1 (0.48) | EGLN1VEGFAFLT1EGLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022036188-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | AKEBIA THERAPEUTICS, INC. (US) | 2022-02-17 | — | — | WO | disclosed |