Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 18/20 | 0.52 |
| ▸ | VEGFA | P15692 | 4/20 | 0.48 |
| ▸ | FLT1 | P17948 | 4/20 | 0.48 |
| ▸ | EGLN3 | Q9H6Z9 | 3/20 | 0.48 |
| ▸ | EGLN2 | Q96KS0 | 4/20 | 0.46 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.44 |
| ▸ | THRA | P10827 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | ASPH | Q12797 | 1/20 | 0.44 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.44 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24257569 | 0.91 | EGLN1 (0.48) | EGLN1EGLN2BBOX1THRATHRB | |
| SCHEMBL24257483 | 0.91 | EGLN1 (0.61) | EGLN1BBOX1THRATHRBSLC6A2 | |
| SCHEMBL24257589 | 0.87 | EGLN1 (0.48) | EGLN1VEGFAFLT1EGLN3THRA | |
| SCHEMBL24257764 | 0.80 | EGLN1 (0.53) | EGLN1VEGFAFLT1EGLN3EGLN2 | |
| SCHEMBL24257751 | 0.80 | EGLN1 (0.50) | EGLN1VEGFAFLT1EGLN3 | |
| SCHEMBL24257710 | 0.79 | EGLN1 (0.52) | EGLN1VEGFAFLT1EGLN3EGLN2 | |
| SCHEMBL29248902 | 0.78 | EGLN1 (0.45) | EGLN1VEGFAFLT1EGLN3 | |
| SCHEMBL28564249 | 0.78 | EGLN1 (0.82) | EGLN1EGLN2THRATHRB | |
| SCHEMBL26260293 | 0.76 | EGLN1 (0.52) | EGLN1VEGFAFLT1EGLN3 | |
| SCHEMBL24257754 | 0.75 | EGLN1 (0.51) | EGLN1VEGFAFLT1EGLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230295110-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | AKEBIA THERAPEUTICS, INC. (US) | 2023-09-21 | — | — | US | disclosed |
| WO-2022036188-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | AKEBIA THERAPEUTICS, INC. (US) | 2022-02-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230295110-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | HIF1AN, EGLN3, PHF20 | EGLN1 19/4885VEGFA 1862/4885FLT1 414/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.