Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC1 | P07992 | 1/20 | 0.42 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 6/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24258089 | 0.82 | ERCC1 (0.45) | ERCC1ERCC4TSHRMAPK1TDP1 | |
| SCHEMBL24258031 | 0.82 | ERCC1 (0.41) | ERCC1ERCC4TSHRMAPK1TDP1 | |
| SCHEMBL24258075 | 0.79 | ERCC1 (0.52) | ERCC1ERCC4TSHRMAPK1TDP1 | |
| SCHEMBL24258081 | 0.77 | ERCC1 (0.45) | ERCC1ERCC4TSHRMAPK1TDP1 | |
| SCHEMBL24258080 | 0.77 | ERCC1 (0.56) | ERCC1ERCC4TSHRMAPK1TDP1 | |
| SCHEMBL26004923 | 0.77 | L3MBTL1 (0.50) | ERCC1ERCC4TSHRMAPK1TDP1 | |
| SCHEMBL24258029 | 0.77 | ERCC1 (0.50) | ERCC1ERCC4TSHRMAPK1TDP1 | |
| SCHEMBL26004989 | 0.77 | ERCC1 (0.44) | ERCC1ERCC4TSHRMAPK1TDP1 | |
| SCHEMBL26004922 | 0.74 | ABL1 (0.44) | ERCC1ERCC4TSHRMAPK1TDP1 | |
| SCHEMBL24258035 | 0.74 | ERCC1 (0.47) | ERCC1ERCC4TSHRMAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022035805-A1 | SUBSTITUTED 1,2,4-OXADIAZOLES AS SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-02-17 | — | — | WO | disclosed |