Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 18/20 | 0.46 |
| ▸ | AURKA | O14965 | 17/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 9/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19640438 | 0.90 | RPS6KB1 (0.47) | RPS6KB1AURKAAURKBEGFR | |
| SCHEMBL19640477 | 0.87 | RPS6KB1 (0.48) | RPS6KB1AURKAAURKBEGFR | |
| SCHEMBL19650854 | 0.84 | RORC (0.41) | RPS6KB1AURKAAURKB | |
| SCHEMBL19650845 | 0.81 | RPS6KB1 (0.42) | RPS6KB1AURKAAURKB | |
| SCHEMBL19640771 | 0.80 | RPS6KB1 (0.43) | RPS6KB1AURKAAURKBEGFR | |
| SCHEMBL29397492 | 0.80 | RPS6KB1 (0.43) | RPS6KB1AURKAAURKBEGFR | |
| SCHEMBL17501311 | 0.79 | RPS6KB1 (0.48) | RPS6KB1AURKAAURKBEGFR | |
| SCHEMBL19640537 | 0.79 | RPS6KB1 (0.44) | RPS6KB1AURKAAURKBEGFR | |
| SCHEMBL19640533 | 0.78 | AURKA (0.42) | RPS6KB1AURKAAURKBEGFR | |
| SCHEMBL19640430 | 0.78 | AURKA (0.41) | RPS6KB1AURKAAURKBEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3177612-B1 | OPTIONALLY FUSED HETEROCYCLYL-SUBSTITUTED DERIVATIVES OF PYRIMIDINE USEFUL FOR THE TREATMENT OF INFLAMMATORY, METABOLIC, ONCOLOGIC AND AUTOIMMUNE DISEASES | NUEVOLUTION AS (DK) | 2022-02-23 | — | — | EP | disclosed |