Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 1/20 | 0.31 |
| ▸ | CCR5 | P51681 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19650941 | 0.83 | CACNA1B (0.35) | CCR2CCR5JAK2JAK1 | |
| SCHEMBL19640694 | 0.78 | CACNA1B (0.37) | CCR2CCR5JAK2JAK1 | |
| SCHEMBL19650873 | 0.75 | AURKA (0.35) | CCR2CCR5 | |
| SCHEMBL19650933 | 0.75 | RORC (0.40) | JAK2JAK1 | |
| SCHEMBL19650849 | 0.74 | RORC (0.39) | JAK2JAK1 | |
| SCHEMBL24258279 | 0.73 | CACNA1B (0.33) | — | |
| SCHEMBL19650884 | 0.72 | TRPV1 (0.36) | — | |
| SCHEMBL19650874 | 0.72 | RORC (0.39) | JAK1 | |
| SCHEMBL19650885 | 0.72 | RORC (0.37) | JAK2JAK1TYK2 | |
| SCHEMBL19650872 | 0.72 | RORC (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3177612-B1 | OPTIONALLY FUSED HETEROCYCLYL-SUBSTITUTED DERIVATIVES OF PYRIMIDINE USEFUL FOR THE TREATMENT OF INFLAMMATORY, METABOLIC, ONCOLOGIC AND AUTOIMMUNE DISEASES | NUEVOLUTION AS (DK) | 2022-02-23 | — | — | EP | disclosed |