Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 6/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 6/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | PNP | P00491 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NT5E | P21589 | 1/20 | 0.34 |
| ▸ | P2RY11 | Q96G91 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RNASE1 | P07998 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.34 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24258664 | 0.84 | LMNA (0.42) | GSK3ARPS6KA3MAPK14LMNAALDH1A1 | |
| SCHEMBL21263936 | 0.83 | LMNA (0.48) | GSK3ARPS6KA3MAPK14LMNAPOLB | |
| SCHEMBL22990426 | 0.79 | GSK3A (0.42) | GSK3ARPS6KA3MAPK14LMNAPOLB | |
| SCHEMBL5386889 | 0.74 | LMNA (0.56) | LMNAALDH1A1NT5ENPC1 | |
| SCHEMBL13084457 | 0.74 | LMNA (0.66) | GSK3ARPS6KA3MAPK14LMNAP2RY11 | |
| SCHEMBL5386883 | 0.74 | LMNA (0.56) | LMNAALDH1A1NT5ENPC1 | |
| SCHEMBL14075786 | 0.74 | LMNA (0.66) | GSK3ARPS6KA3MAPK14LMNAP2RY11 | |
| SCHEMBL22992449 | 0.74 | POLB (0.48) | POLBMEN1USP2KMT2ANT5E | |
| SCHEMBL23750660 | 0.73 | POLB (0.52) | POLBALDH1A1MEN1USP2KMT2A | |
| SCHEMBL20725049 | 0.73 | LMNA (0.47) | GSK3ARPS6KA3MAPK14LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3752516-B1 | CYCLIC DINUCLEOTIDES AS ANTICANCER AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2022-02-23 | — | — | EP | disclosed |