Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26B1 | Q9NR63 | 4/20 | 0.71 |
| ▸ | RXRA | P19793 | 10/20 | 0.60 |
| ▸ | CYP26A1 | O43174 | 6/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.57 |
| ▸ | RARB | P10826 | 9/20 | 0.44 |
| ▸ | RARG | P13631 | 9/20 | 0.44 |
| ▸ | RARA | P10276 | 7/20 | 0.44 |
| ▸ | RXRB | P28702 | 4/20 | 0.39 |
| ▸ | RXRG | P48443 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GMNN | O75496 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17911582 | 0.83 | CYP26B1 (1.00) | CYP26B1RXRACYP26A1CYP3A4RARB | |
| SCHEMBL17911581 | 0.83 | CYP26B1 (1.00) | CYP26B1RXRACYP26A1CYP3A4RARB | |
| SCHEMBL17914358 | 0.80 | CYP26B1 (0.77) | CYP26B1RXRACYP26A1CYP3A4RARB | |
| SCHEMBL8902795 | 0.78 | RARB (0.59) | CYP26B1RXRACYP26A1CYP3A4RARB | |
| SCHEMBL8902801 | 0.78 | RARB (0.59) | CYP26B1RXRACYP26A1CYP3A4RARB | |
| SCHEMBL24259953 | 0.78 | CYP26B1 (0.71) | CYP26B1RXRACYP26A1CYP3A4RARB | |
| SCHEMBL2808583 | 0.75 | RXRA (1.00) | CYP26B1RXRACYP26A1CYP3A4RARB | |
| SCHEMBL17911572 | 0.73 | CYP26B1 (1.00) | CYP26B1RXRACYP26A1CYP3A4RXRB | |
| SCHEMBL8708782 | 0.72 | RXRA (0.74) | CYP26B1RXRACYP26A1CYP3A4RARB | |
| SCHEMBL24259975 | 0.70 | CYP26A1 (0.76) | CYP26B1RXRACYP26A1CYP3A4RARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3044216-B1 | NOVEL AND SPECIFIC INHIBITORS OF CYTOCHROME P450 26 RETINOIC ACID HYDROXYLASE | UNIV WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (US) | 2022-02-23 | — | — | EP | disclosed |