Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 8/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.72 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.72 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.72 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.72 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPY1R | P25929 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPY2R | P49146 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Talarozole SCHEMBL4984008 | 0.84 | CYP26A1 (1.00) | CYP26A1CYP3A4CYP2C9CYP2C8CYP26B1 | |
| Talarozole SCHEMBL721201 | 0.84 | CYP26A1 (1.00) | CYP26A1CYP3A4CYP2C9CYP2C8CYP26B1 | |
| Talarozole SCHEMBL3739251 | 0.84 | CYP26A1 (1.00) | CYP26A1CYP3A4CYP2C9CYP2C8CYP26B1 | |
| Talarozole SCHEMBL21020998 | 0.84 | CYP26A1 (1.00) | CYP26A1CYP3A4CYP2C9CYP2C8CYP26B1 | |
| SCHEMBL4982977 | 0.77 | CYP26A1 (0.65) | CYP26A1CYP3A4CYP2C9CYP2C8CYP26B1 | |
| SCHEMBL4983683 | 0.72 | CYP26A1 (0.63) | CYP26A1CYP3A4CYP2C9CYP2C8CYP26B1 | |
| SCHEMBL9005425 | 0.72 | CYP26A1 (0.77) | CYP26A1CYP3A4CYP2C9CYP2C8CYP26B1 | |
| SCHEMBL9005429 | 0.71 | CYP26A1 (0.76) | CYP26A1CYP3A4CYP2C9CYP2C8CYP26B1 | |
| SCHEMBL13642299 | 0.70 | CYP26A1 (0.73) | CYP26A1CYP3A4CYP2C9CYP2C8CYP26B1 | |
| SCHEMBL4986440 | 0.69 | CYP26A1 (1.00) | CYP26A1CYP3A4CYP2C9CYP2C8CYP26B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3044216-B1 | NOVEL AND SPECIFIC INHIBITORS OF CYTOCHROME P450 26 RETINOIC ACID HYDROXYLASE | UNIV WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (US) | 2022-02-23 | — | — | EP | disclosed |