Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 7/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.76 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.76 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.76 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.76 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
| ▸ | SCD | O00767 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 2/20 | 0.36 |
| ▸ | SULT1A1 | P50225 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14221922 | 0.95 | CYP26A1 (0.68) | CYP26A1CYP3A4CYP2C9CYP2C8CYP26B1 | |
| SCHEMBL9005425 | 0.90 | CYP26A1 (0.77) | CYP26A1CYP3A4CYP2C9CYP2C8CYP26B1 | |
| SCHEMBL13642299 | 0.87 | CYP26A1 (0.73) | CYP26A1CYP3A4CYP2C9CYP2C8CYP26B1 | |
| Talarozole SCHEMBL21020998 | 0.86 | CYP26A1 (1.00) | CYP26A1CYP3A4CYP2C9CYP2C8CYP26B1 | |
| Talarozole SCHEMBL721201 | 0.86 | CYP26A1 (1.00) | CYP26A1CYP3A4CYP2C9CYP2C8CYP26B1 | |
| Talarozole SCHEMBL4984008 | 0.86 | CYP26A1 (1.00) | CYP26A1CYP3A4CYP2C9CYP2C8CYP26B1 | |
| Talarozole SCHEMBL3739251 | 0.86 | CYP26A1 (1.00) | CYP26A1CYP3A4CYP2C9CYP2C8CYP26B1 | |
| SCHEMBL9005469 | 0.85 | CYP26A1 (0.57) | CYP26A1CYP3A4CYP2C9CYP2C8CYP26B1 | |
| SCHEMBL13642547 | 0.84 | CYP26A1 (0.67) | CYP26A1CYP3A4CYP2C9CYP2C8CYP26B1 | |
| SCHEMBL9005692 | 0.83 | CYP26A1 (0.65) | CYP26A1CYP3A4CYP2C9CYP2C8CYP26B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399495-B2 | Talarazole metabolites | STIEFEL LABORATORIES, INC. (US) | 2013-03-19 | — | — | US | disclosed |
| US-8399495-B2 | Talarazole metabolites | STIEFEL LABORATORIES, INC. (US) | 2013-03-19 | — | — | US | disclosed |
| US-20120283204-A1 | TALARAZOLE METABOLITES | BARRETT DEBRA (US) | 2012-11-08 | — | — | US | disclosed |
| US-20120283204-A1 | TALARAZOLE METABOLITES | BARRETT DEBRA (US) | 2012-11-08 | — | — | US | disclosed |
| US-8188124-B2 | Talarazole metabolites | STIEFEL LABORATORIES, INC. (US) | 2012-05-29 | — | — | US | disclosed |
| US-8188124-B2 | Talarazole metabolites | STIEFEL LABORATORIES, INC. (US) | 2012-05-29 | — | — | US | disclosed |
| US-20100292284-A1 | Talarazole metabolites | STIEFEL LABORATORIES, INC. (US) | 2010-11-18 | — | — | US | disclosed |
| US-20100292284-A1 | Talarazole metabolites | STIEFEL LABORATORIES, INC. (US) | 2010-11-18 | — | — | US | disclosed |
| WO-2008049027-A1 | TALARAZOLE METABOLITES | STIEFEL LABORATORIES, INC. (US) | 2008-04-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292284-A1 | Talarazole metabolites | UGT1A3, GRHPR, UGT1A7 | CYP26A1 29/4885CYP3A4 85/4885CYP2C9 52/4885 |
| US-20120283204-A1 | TALARAZOLE METABOLITES | UGT1A3, GRHPR, UGT1A7 | CYP26A1 29/4885CYP3A4 85/4885CYP2C9 52/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.