Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24260878 | 0.89 | HTR6 (0.36) | HTR6KDM2B | |
| SCHEMBL4825714 | 0.88 | HTR6 (0.41) | HTR6HPGDKMT2ASMN1; SMN2HRH3 | |
| SCHEMBL21622614 | 0.79 | HTR6 (0.43) | HTR6HPGDKMT2ASMN1; SMN2HRH3 | |
| SCHEMBL24260750 | 0.78 | KDM2B (0.39) | KDM2BHRH3 | |
| SCHEMBL19625756 | 0.78 | HPGD (0.40) | HTR6HPGDKMT2ASMN1; SMN2HRH3 | |
| SCHEMBL14423644 | 0.74 | HTR6 (0.39) | HTR6HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL19797934 | 0.73 | KDM2B (0.34) | KDM2B | |
| SCHEMBL4481058 | 0.71 | HRH3 (0.34) | HTR6HPGDKMT2ASMN1; SMN2HRH3 | |
| SCHEMBL9315571 | 0.71 | MAPK1 (0.46) | HTR6HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL10863656 | 0.71 | HRH3 (0.34) | HTR6HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3242875-B1 | 4,5-DIHYDROIMIDAZOLE DERIVATIVES AND THEIR USE AS HISTONE DEMETHYLASE (KDM2B) INHIBITORS | GENENTECH INC (US) | 2022-02-23 | — | — | EP | disclosed |