Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 6/20 | 0.42 |
| ▸ | ATP4A | P20648 | 3/20 | 0.42 |
| ▸ | ATP4B | P51164 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | GHSR | Q92847 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2450562 | 0.82 | NPC1 (0.55) | NPC1RAB9AKMT2AATP4AATP4B | |
| SCHEMBL2426475 | 0.79 | NPC1 (0.47) | NPC1RAB9AKMT2ACSNK1DKDM4E | |
| Fumaric Acid SCHEMBL2380818 | 0.73 | NPC1 (0.46) | NPC1RAB9AKMT2ACSNK1DKDM4E | |
| SCHEMBL2379807 | 0.73 | ATP4A (0.59) | ATP4AATP4B | |
| SCHEMBL2448781 | 0.72 | ATP4A (0.57) | NPC1RAB9AKMT2AATP4AATP4B | |
| SCHEMBL2380575 | 0.72 | ATP4A (0.69) | ATP4AATP4B | |
| SCHEMBL2443764 | 0.72 | ATP4A (0.60) | ATP4AATP4B | |
| SCHEMBL2379505 | 0.72 | NPC1 (0.55) | NPC1RAB9AKMT2ACSNK1DATP4A | |
| SCHEMBL2379141 | 0.71 | ATP4A (0.56) | ATP4AATP4B | |
| Bromide SCHEMBL2378100 | 0.71 | ATP4A (0.59) | NPC1RAB9AKMT2AATP4AATP4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716127-B1 | GUANIDINE COMPOUNDS, AND USE THEREOF AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | ABBVIE DEUTSCHLAND (DE) | 2014-08-06 | — | — | EP | disclosed |
| EP-2380885-A1 | Guanidine compounds and use of same as binding partners for 5-HT5 receptors | Abbott GmbH & Co. KG (DE) | 2011-10-26 | — | — | EP | disclosed |
| EP-2366392-A1 | Guanidine compounds and use of same as binding partners for 5-HT5 receptors | Abbott GmbH & Co. KG (DE) | 2011-09-21 | — | — | EP | disclosed |
| EP-2366697-A1 | Guanidine compounds and use of same as binding partners for 5-HT5 receptors | Abbott GmbH & Co. KG (DE) | 2011-09-21 | — | — | EP | disclosed |
| EP-1716127-A2 | GUANIDINE COMPOUNDS, AND USE THEREOF AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | Abbott GmbH & Co. KG (DE) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005082871-A2 | GUANIDINE COMPOUNDS, AND USE THEREOF AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | ABBOTT GMBH & CO. KG (DE) | 2005-09-09 | — | — | WO | disclosed |