Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 7/20 | 0.47 |
| ▸ | RAB9A | P51151 | 7/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | PLK1 | P53350 | 1/20 | 0.44 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.44 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.44 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HNF4A | P41235 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2432790 | 0.90 | PIM1 (0.43) | PIM1PIM3NPC1RAB9ACASP3 | |
| SCHEMBL2433136 | 0.87 | PIM1 (0.41) | PIM1PIM3NPC1RAB9ACASP3 | |
| SCHEMBL14871602 | 0.79 | MAPT (0.44) | NPC1RAB9AMAPTALDH1A1KDM4E | |
| SCHEMBL12324331 | 0.79 | MAPT (0.44) | NPC1RAB9AMAPTALDH1A1KDM4E | |
| SCHEMBL2432112 | 0.78 | MAPT (0.49) | NPC1RAB9AMAPTALDH1A1KDM4E | |
| SCHEMBL2429295 | 0.78 | MAPT (0.43) | NPC1RAB9AMAPTALDH1A1KDM4E | |
| SCHEMBL2430190 | 0.76 | NPC1 (0.53) | NPC1RAB9ACASP3SENP7MAPT | |
| SCHEMBL2425567 | 0.76 | NPC1 (0.53) | NPC1RAB9ACASP3SENP7MAPT | |
| SCHEMBL2430174 | 0.76 | NPC1 (0.53) | NPC1RAB9ACASP3SENP7MAPT | |
| SCHEMBL2493258 | 0.76 | NPC1 (0.53) | NPC1RAB9ACASP3SENP7MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2542239-A1 | USE OF ISOQUINOLONES FOR PREPARING DRUGS, NOVEL ISOQUINOLONES AND METHOD FOR SYNTHESISING SAME | Université Joseph Fourier (FR) | 2013-01-09 | — | — | EP | disclosed |
| WO-2011107709-A1 | USE OF ISOQUINOLONES FOR PREPARING DRUGS, NOVEL ISOQUINOLONES AND METHOD FOR SYNTHESISING SAME | UNIVERSITE JOSEPH FOURIER (FR) | 2011-09-09 | — | — | WO | disclosed |