Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.79 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.79 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.64 |
| ▸ | MAPT | P10636 | 4/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | STAT3 | P40763 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10849323 | 0.80 | CYP1A2 (0.62) | CYP1A2CYP3A4CYP2C19ALDH1A1MAPT | |
| SCHEMBL15245305 | 0.78 | CYP2C19 (0.57) | CYP1A2CYP3A4CYP2C19ALDH1A1MAPT | |
| SCHEMBL3396574 | 0.78 | STAT3 (0.74) | CYP1A2CYP3A4CYP2C19ALDH1A1MAPT | |
| SCHEMBL1851840 | 0.76 | KMT2A (0.73) | ALDH1A1MAPTLMNAHPGDKDM4E | |
| SCHEMBL1850889 | 0.75 | KMT2A (0.76) | ALDH1A1MAPTLMNAHPGDKDM4E | |
| SCHEMBL5158468 | 0.74 | RAB9A (0.65) | CYP1A2ALDH1A1MAPTKMT2AGAA | |
| SCHEMBL2263678 | 0.74 | KMT2A (0.97) | ALDH1A1MAPTLMNAHPGDKDM4E | |
| SCHEMBL1850843 | 0.73 | KMT2A (0.69) | ALDH1A1MAPTLMNAHPGDKDM4E | |
| SCHEMBL9999239 | 0.73 | STAT3 (0.67) | CYP1A2CYP3A4CYP2C19MAPTSTAT3 | |
| SCHEMBL11550121 | 0.73 | KMT2A (1.00) | ALDH1A1MAPTLMNAKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4213839-A2 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS | ESCIENT PHARMACEUTICALS, INC. (US) | 2023-07-26 | — | — | EP | disclosed |
| CN-116438162-A | Modulators of MAS-related G protein receptor X4 and related products and methods | 伊赛恩特制药公司 | 2023-07-14 | — | — | CN | disclosed |
| WO-2022061008-A2 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS | ESCIENT PHARMACEUTICALS, INC. (US) | 2022-03-24 | — | — | WO | disclosed |
| WO-2022061008-A2 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS | ESCIENT PHARMACEUTICALS, INC. (US) | 2022-03-24 | — | — | WO | disclosed |