Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 2/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | FER | P16591 | 1/20 | 0.40 |
| ▸ | LTK | P29376 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | CCR6 | P51684 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.36 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8874017 | 0.83 | GSK3B (0.56) | ACVR1LRRK2PDGFRAFERLTK | |
| SCHEMBL8874013 | 0.83 | GSK3B (0.56) | ACVR1LRRK2PDGFRAFERLTK | |
| SCHEMBL309801 | 0.72 | GSK3B (0.46) | GSK3BGAAMAPTCYP1A2MEN1 | |
| SCHEMBL1996673 | 0.71 | MAPT (0.38) | ACVR1LRRK2PDGFRAFERLTK | |
| SCHEMBL29848588 | 0.71 | MAPT (0.38) | ACVR1LRRK2PDGFRAFERLTK | |
| SCHEMBL7440282 | 0.67 | MAPT (0.56) | ACVR1LRRK2PDGFRAFERLTK | |
| SCHEMBL7440281 | 0.67 | MAPT (0.56) | ACVR1LRRK2PDGFRAFERLTK | |
| SCHEMBL14559393 | 0.66 | ACVR1 (0.52) | ACVR1LRRK2PDGFRAFERLTK | |
| SCHEMBL5697347 | 0.66 | ACVR1 (0.67) | ACVR1LRRK2PDGFRAFERLTK | |
| SCHEMBL10671049 | 0.65 | MAPT (0.54) | ACVR1LRRK2PDGFRAFERLTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1540329-A4 | DRUG DISCOVERY METHOD | KEDDEM BIO SCIENCE LTD (IL) | 2009-06-10 | — | — | EP | claimed |
| JP-2006507480-A | — | — | 2006-03-02 | — | — | JP | claimed |
| EP-1540329-A1 | DRUG DISCOVERY METHOD | KEDDEM BIO-SCIENCE LTD. (IL) | 2005-06-15 | — | — | EP | claimed |
| WO-2004010136-A1 | DRUG DISCOVERY METHOD | KEDDEM BIO-SCIENCE LTD. (IL) | 2004-01-29 | — | — | WO | claimed |
| US-20160314241-A1 | DRUG DISCOVERY METHOD | Keddem Bioscience Ltd. (IL) | 2016-10-27 | — | — | US | disclosed |
| US-20160314241-A1 | DRUG DISCOVERY METHOD | Keddem Bioscience Ltd. (IL) | 2016-10-27 | — | — | US | disclosed |
| US-20160314241-A1 | DRUG DISCOVERY METHOD | Keddem Bioscience Ltd. (IL) | 2016-10-27 | — | — | US | disclosed |
| US-9405885-B2 | Drug discovery method | Keddem Bioscience Ltd. (IL) | 2016-08-02 | — | — | US | disclosed |
| US-9405885-B2 | Drug discovery method | Keddem Bioscience Ltd. (IL) | 2016-08-02 | — | — | US | disclosed |
| US-9405885-B2 | Drug discovery method | Keddem Bioscience Ltd. (IL) | 2016-08-02 | — | — | US | disclosed |
| EP-2581849-A1 | Drug discovery method | KEDDEM BIO-SCIENCE LTD. (IL) | 2013-04-17 | — | — | EP | disclosed |
| EP-2581849-A1 | Drug discovery method | KEDDEM BIO-SCIENCE LTD. (IL) | 2013-04-17 | — | — | EP | disclosed |
| EP-1540329-A4 | DRUG DISCOVERY METHOD | KEDDEM BIO SCIENCE LTD (IL) | 2009-06-10 | — | — | EP | disclosed |
| EP-1651234-A1 | COMBINATION OF MGLUR2 ANTAGONIST AND ACHE INHIBITOR FOR TREATMENT OF ACUTE AND/OR CHRONIC NEUROLOGICAL DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-05-03 | — | — | EP | disclosed |
| US-20050277117-A1 | Drug discovery method | KEDDEM BIO-SCIENCE LTD. (IL) | 2005-12-15 | — | — | US | disclosed |
| EP-1540329-A1 | DRUG DISCOVERY METHOD | KEDDEM BIO-SCIENCE LTD. (IL) | 2005-06-15 | — | — | EP | disclosed |
| WO-2005014002-A1 | COMBINATION OF MGLUR2 ANTAGONIST AND ACHE INHIBITOR FOR TREATMENT OF ACUTE AND/OR CHRONIC NEUROLOGICAL DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-02-17 | — | — | WO | disclosed |
| WO-2004010136-A1 | DRUG DISCOVERY METHOD | KEDDEM BIO-SCIENCE LTD. (IL) | 2004-01-29 | — | — | WO | disclosed |
| US-4764512-A | Benzodiazinone-pyridone compounds, cardiotonic compositions including the same, and their uses | RORER PHARMACEUTICAL CORPORATION (US) | 1988-08-16 | — | — | US | disclosed |
| US-4123430-A | 2-Aryl-4-(1-piperazinyl)-3H-1,5-benzodiazepines | G. D. SEARLE & CO. (US) | 1978-10-31 | — | — | US | disclosed |