Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 14/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 14/20 | 0.53 |
| ▸ | PKM | P14618 | 6/20 | 0.53 |
| ▸ | POLB | P06746 | 12/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.51 |
| ▸ | MAPT | P10636 | 11/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 10/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.51 |
| ▸ | BLM | P54132 | 9/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 9/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.51 |
| ▸ | GAA | P10253 | 6/20 | 0.51 |
| ▸ | APEX1 | P27695 | 4/20 | 0.51 |
| ▸ | USP2 | O75604 | 3/20 | 0.51 |
| ▸ | PTGES | O14684 | 1/20 | 0.51 |
| ▸ | MGAM | O43451 | 2/20 | 0.50 |
| ▸ | SI | P14410 | 2/20 | 0.50 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 8/20 | 0.47 |
| ▸ | RECQL | P46063 | 7/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24277568 | 0.80 | MEN1 (0.73) | MEN1KMT2APKMPOLBALDH1A1 | |
| SCHEMBL24277923 | 0.78 | SMPD3 (0.45) | MEN1KMT2APOLBALDH1A1MAPT | |
| SCHEMBL26293182 | 0.77 | MEN1 (0.82) | MEN1KMT2APKMPOLBALDH1A1 | |
| SCHEMBL26761824 | 0.75 | MEN1 (0.68) | MEN1KMT2APKMPOLBALDH1A1 | |
| SCHEMBL26294556 | 0.72 | MEN1 (0.73) | MEN1KMT2APKMPOLBALDH1A1 | |
| SCHEMBL26293211 | 0.71 | MEN1 (0.75) | MEN1KMT2APKMPOLBALDH1A1 | |
| SCHEMBL26294624 | 0.70 | MEN1 (0.86) | MEN1KMT2APKMPOLBALDH1A1 | |
| SCHEMBL26296124 | 0.67 | MEN1 (1.00) | MEN1KMT2APKMPOLBALDH1A1 | |
| SCHEMBL6722302 | 0.67 | MCL1 (0.77) | MEN1KMT2APKMPOLBALDH1A1 | |
| SCHEMBL6262120 | 0.66 | MEN1 (1.00) | MEN1KMT2APKMPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022056068-A1 | SMALL MOLECULE INHIBITORS OF ENPP1 | THE REGENTS OF THE UNIVERSITY OFCALIFORNIA (US) | 2022-03-17 | — | — | WO | disclosed |