Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 16/20 | 0.52 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.49 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.45 |
| ▸ | CPT2 | P23786 | 1/20 | 0.38 |
| ▸ | CPT1A | P50416 | 1/20 | 0.38 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | PKLR | P30613 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18312294 | 0.90 | RORC (0.64) | RORCNR1I2PKMPKLR | |
| SCHEMBL24286730 | 0.88 | RORC (0.50) | RORCNR1I2NR1H3NR1H2 | |
| SCHEMBL24286481 | 0.83 | RORC (0.57) | RORCNR1I2NR1H3PKMPKLR | |
| SCHEMBL24286517 | 0.83 | RORC (0.47) | RORCNR1I2NR1H3NR1H2CPT2 | |
| SCHEMBL24286464 | 0.82 | RORC (0.55) | RORCNR1I2NR1H3NR1H2PKM | |
| SCHEMBL24286470 | 0.81 | RORC (0.55) | RORCNR1I2NR1H3NR1H2PKM | |
| SCHEMBL24286212 | 0.81 | RORC (0.55) | RORCNR1I2PKMPKLR | |
| SCHEMBL24286199 | 0.81 | RORC (0.55) | RORCNR1I2CPT2CPT1ACPT1B | |
| SCHEMBL24286607 | 0.80 | RORC (0.55) | RORCNR1I2PKMPKLR | |
| SCHEMBL24286178 | 0.80 | RORC (0.57) | RORCNR1I2PKMPKLR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3307738-B1 | ARYL DIHYDRO-2H-BENZO[B][1,4]OXAZINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORY AND THE TREATMENT OF DISEASE | UNIV MICHIGAN REGENTS (US) | 2022-04-20 | — | — | EP | disclosed |