Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 7/20 | 0.44 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | BCL6 | P41182 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
| ▸ | MAPK6 | Q16659 | 3/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL30838108 | 0.99 | MAPK8 (0.43) | MAPK8EIF2AK2MAPK9ADORA2AADORA1 | |
| SCHEMBL30838069 | 0.82 | IRAK4 (0.41) | MAPK8ADORA2AADORA1MAPK6MCHR1 | |
| Hydrochloric Acid SCHEMBL30838058 | 0.79 | CCNK (0.44) | ADORA2AADORA1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL30837996 | 0.78 | NSD2 (0.44) | MAPK8ADORA2AADORA1BCL6MAPT | |
| SCHEMBL30838096 | 0.75 | CDK2 (0.40) | MAPK8MAPK9MCHR1 | |
| SCHEMBL30838060 | 0.72 | CYP11B1 (0.41) | MAPK6SYK | |
| Hydrochloric Acid SCHEMBL30838012 | 0.72 | CYP11B1 (0.41) | MAPK6SYK | |
| SCHEMBL30838013 | 0.71 | IRAK4 (0.40) | MAPK8ADORA2AADORA1MAPK6MCHR1 | |
| SCHEMBL24288146 | 0.70 | HRH4 (0.42) | ADORA2AADORA1AXL | |
| SCHEMBL24288103 | 0.70 | IRAK4 (0.39) | MAPK8ADORA2AADORA1MAPK6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022053823-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AS NICOTINIC ACETYLCHOLINESTERASE RECEPTOR ALPHA 6 MODULATOR | Cerevance, Inc. (US) | 2022-03-17 | — | — | WO | disclosed |