Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK6 | Q16659 | 6/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | GPR6 | P46095 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27095200 | 0.89 | MAPK8 (0.39) | IRAK4MAPK8ADORA1GPR6 | |
| SCHEMBL30838069 | 0.87 | IRAK4 (0.41) | IRAK4MAPK8MAPK6ADORA2AADORA1 | |
| SCHEMBL30838013 | 0.85 | IRAK4 (0.40) | IRAK4MAPK8MAPK6ADORA2AADORA1 | |
| SCHEMBL30838096 | 0.70 | CDK2 (0.40) | MAPK8 | |
| SCHEMBL24288095 | 0.70 | MAPK8 (0.44) | MAPK8MAPK6ADORA2AADORA1MAPT | |
| Hydrochloric Acid SCHEMBL30838108 | 0.69 | MAPK8 (0.43) | MAPK8MAPK6ADORA2AADORA1MAPT | |
| SCHEMBL18830394 | 0.69 | MAPK6 (0.43) | IRAK4MAPK6ADORA2A | |
| SCHEMBL30837994 | 0.67 | MAPK8 (0.39) | IRAK4MAPK8 | |
| Hydrochloric Acid SCHEMBL30838027 | 0.66 | MAPK8 (0.39) | IRAK4MAPK8 | |
| SCHEMBL17435247 | 0.65 | MAPK6 (0.76) | MAPK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022053823-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AS NICOTINIC ACETYLCHOLINESTERASE RECEPTOR ALPHA 6 MODULATOR | Cerevance, Inc. (US) | 2022-03-17 | — | — | WO | disclosed |