Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methadone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 6/20 | 0.97 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.97 |
| ▸ | GRIN2A | Q12879 | 6/20 | 0.97 |
| ▸ | GRIN2D | O15399 | 5/20 | 0.97 |
| ▸ | GRIN2C | Q14957 | 5/20 | 0.97 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.97 |
| ▸ | DRD3 | P35462 | 3/20 | 0.97 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.97 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.97 |
| ▸ | DRD4 | P21917 | 2/20 | 0.97 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.97 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.97 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.97 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.97 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.97 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.97 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.97 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.97 |
| ▸ | DRD2 | P14416 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methadone SCHEMBL5486844 | 1.00 | GRIN1 (0.97) | GRIN1GRIN2AOPRM1GRIN2DGRIN2C | |
| Methadone SCHEMBL1369177 | 1.00 | GRIN1 (0.97) | GRIN1GRIN2AOPRM1GRIN2DGRIN2C | |
| Methadone SCHEMBL7107052 | 1.00 | GRIN1 (0.97) | GRIN1GRIN2AOPRM1GRIN2DGRIN2C | |
| Methadone SCHEMBL3426247 | 1.00 | GRIN1 (0.97) | GRIN1GRIN2AOPRM1GRIN2DGRIN2C | |
| Esmethadone SCHEMBL6055296 | 1.00 | GRIN1 (0.97) | GRIN1GRIN2AOPRM1GRIN2DGRIN2C | |
| Levomethadone SCHEMBL396161 | 1.00 | GRIN1 (0.97) | GRIN1GRIN2AOPRM1GRIN2DGRIN2C | |
| Methadone SCHEMBL18321925 | 1.00 | GRIN1 (0.97) | GRIN1GRIN2AOPRM1GRIN2DGRIN2C | |
| Methadone SCHEMBL23589519 | 0.98 | GRIN1 (0.94) | GRIN1GRIN2AOPRM1GRIN2DGRIN2C | |
| Methadone SCHEMBL8988558 | 0.98 | GRIN1 (0.94) | GRIN1GRIN2AOPRM1GRIN2DGRIN2C | |
| Methadone SCHEMBL2855175 | 0.98 | GRIN1 (0.94) | GRIN1GRIN2AOPRM1GRIN2DGRIN2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 26999 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4473961-A1 | ORAL SOLID PHARMACEUTICAL FORMULATION COMPRISING METHADONE/LEVOMETHADONE AND OPTIONALLY NALOXONE | L. MOLTENI & C. DEI FRATELLI ALITTI SOCIETA' DI ESERCIZIO S.p.A. (IT) | 2024-12-11 | — | — | EP | claimed |
| US-20240282425-A1 | AUTHENTICATION METHODS AND SYSTEMS FOR DISPENSED PRESCRIPTIONS | LOW GORDON KEITH (US) | 2024-08-22 | — | — | US | claimed |
| EP-3746534-B1 | PARTICULATE LAUNDRY SOFTENING WASH ADDITIVE | PROCTER & GAMBLE (US) | 2024-07-17 | — | — | EP | claimed |
| EP-3520785-B1 | USES OF BACTERIOSTATIC AGENT FORMULA IN PREPARING COMPOSITION FOR VAGINAL USE AND COMPOSITION FOR VAGINAL USE | SHENZHEN EULIKAN BIOTECHNOLOGY CO LTD (CN) | 2024-07-17 | — | — | EP | claimed |
| EP-2953647-B1 | POSITIVELY CHARGED POLYSACCHARIDES FOR RNA TRANSFECTION | B G NEGEV TECH AND APPLICATIONS LTD (IL) | 2024-07-17 | — | — | EP | claimed |
| EP-4245296-B1 | COMPOSITIONS IN THE FORM OF DISSOLVABLE SOLID STRUCTURES | PROCTER & GAMBLE (US) | 2024-07-17 | — | — | EP | claimed |
| EP-3752756-B1 | ROTARY VALVE | TALIS BIOMEDICAL CORP (US) | 2024-07-17 | — | — | EP | claimed |
| EP-4125399-B1 | COMPOSITION FOR FERMENTED OR ACIDIFIED MILK PRODUCTS, ITS USE, PRODUCTS CONTAINING THE SAME AND PROCESS FOR THE PRODUCTION OF THESE PRODUCTS | INT N&H DENMARK APS (DK) | 2024-07-10 | — | — | EP | claimed |
| EP-4054394-B1 | WIPE FOR CLEANING AND DISINFECTING OBJECTS AND SURFACES | CMC CONSUMER MEDICAL CARE GMBH (DE) | 2024-07-10 | — | — | EP | claimed |
| EP-4026818-B1 | FULL-FIBER BURNER TILE AND MANUFACTURING METHOD THEREFOR | LUYANG ENERGY SAVING MAT CO LTD (CN) | 2024-07-03 | — | — | EP | claimed |
| EP-0001501-B1 | METHOD OF BONDING LIGNOCELLULOSIC MATERIAL | Jansky, John, Dr. (FR) | 1982-08-25 | — | — | EP | claimed |
| WO-1982001649-A1 | NEW GALENIC PREPARATION OF PHENOFIBRATE,METHOD FOR THE OBTENTION THEREOF,ITS APPLICATION AS A MEDICINE | LARUELLE CLAUDE | 1982-05-27 | — | — | WO | claimed |
| EP-0000820-B1 | PROCESS FOR OBTAINING LARGE GRANULE STARCH PROTECTIVE MATERIAL FOR PRESSURE SENSITIVE MICROENCAPSULATED COATINGS | A.E. STALEY MANUFACTURING COMPANY (US) | 1982-03-31 | — | — | EP | claimed |
| EP-0006362-B1 | PROCESS FOR THE PRODUCTION OF NON-COMBUSTIBLE ASBESTOS-FREE BOARD PRODUCTS | T&N Materials Research Limited (GB) | 1982-01-13 | — | — | EP | claimed |
| EP-0037300-A1 | Whipping compositions and dessert products and method for their preparation | RHONE-POULENC SPECIALITES CHIMIQUES (FR) | 1981-10-07 | — | — | EP | claimed |
| EP-0007801-B1 | A PROCESS FOR PREPARING A STABLE, HIGH SURFACE ALPHA-ALUMINA FROM GAMMA-ALUMINA | EXXON RESEARCH AND ENGINEERING COMPANY (US) | 1981-08-26 | — | — | EP | claimed |
| EP-0031050-A2 | Process for preparing a pulverulent starchy foodstuff easily miscible with water | SOCIETE DES PRODUITS NESTLE S.A. (CH) | 1981-07-01 | — | — | EP | claimed |
| EP-0015236-A1 | Incombustible adhesive-binder composition based on alkali silicate, process for its production, and application | Société de Diffusion de Recherches Techniques et Financières S.A. (CH) | 1980-09-03 | — | — | EP | claimed |
| EP-0006390-A1 | Process of forming a fibrous web by the papermaking technique in order to improve the binding and retention, web obtained by this process and its use as a substitute material for asbestos products and as a printing or writing support | ARJOMARI-PRIOUX S.A. (FR) | 1980-01-09 | — | — | EP | claimed |
| US-4126684-A | 4-AMINO-3-P-HALOPHENYLBUTYRIC ACIDS AND THEIR DERIVATIVES USED IN THE CONTROL OF NARCOTIC ABUSE | CIBA-GEIGY CORPORATION (US) | 1978-11-21 | — | — | US | claimed |