Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methadone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 6/20 | 0.94 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.94 |
| ▸ | GRIN2A | Q12879 | 6/20 | 0.94 |
| ▸ | GRIN2D | O15399 | 5/20 | 0.94 |
| ▸ | GRIN2C | Q14957 | 5/20 | 0.94 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.94 |
| ▸ | DRD3 | P35462 | 3/20 | 0.94 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.94 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.94 |
| ▸ | DRD4 | P21917 | 2/20 | 0.94 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.94 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.94 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.94 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.94 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.94 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.94 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.94 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.94 |
| ▸ | DRD2 | P14416 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methadone SCHEMBL23589519 | 1.00 | GRIN1 (0.94) | GRIN1GRIN2AOPRM1GRIN2DGRIN2C | |
| Levomethadone SCHEMBL396161 | 0.98 | GRIN1 (0.97) | GRIN1GRIN2AOPRM1GRIN2DGRIN2C | |
| Methadone SCHEMBL5486844 | 0.98 | GRIN1 (0.97) | GRIN1GRIN2AOPRM1GRIN2DGRIN2C | |
| Methadone SCHEMBL3426247 | 0.98 | GRIN1 (0.97) | GRIN1GRIN2AOPRM1GRIN2DGRIN2C | |
| Esmethadone SCHEMBL6055296 | 0.98 | GRIN1 (0.97) | GRIN1GRIN2AOPRM1GRIN2DGRIN2C | |
| Methadone SCHEMBL24293 | 0.98 | GRIN1 (0.97) | GRIN1GRIN2AOPRM1GRIN2DGRIN2C | |
| Methadone SCHEMBL18321925 | 0.98 | GRIN1 (0.97) | GRIN1GRIN2AOPRM1GRIN2DGRIN2C | |
| Methadone SCHEMBL1369177 | 0.98 | GRIN1 (0.97) | GRIN1GRIN2AOPRM1GRIN2DGRIN2C | |
| Methadone SCHEMBL7107052 | 0.98 | GRIN1 (0.97) | GRIN1GRIN2AOPRM1GRIN2DGRIN2C | |
| Methadone SCHEMBL8988558 | 0.97 | GRIN1 (0.94) | GRIN1GRIN2AOPRM1GRIN2DGRIN2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1515701-B1 | PROCESS FOR THE MANUFACTURE OF MULTILAYER TABLET COMPOSITIONS COMPRISING THIAZOLIDINEDIONE AND BIGUANIDE | INVENTIA HEALTHCARE PRIVATE LTD (IN) | 2014-09-17 | — | — | EP | claimed |
| EP-1267880-B2 | LOW DOSE ENTECAVIR FORMULATION AND USE | BRISTOL MYERS SQUIBB CO (US) | 2010-01-20 | — | — | EP | claimed |
| EP-1145711-B1 | Flash-melt oral dosage formulation | BRISTOL MYERS SQUIBB CO (US) | 2006-06-07 | — | — | EP | claimed |
| EP-1267880-B1 | LOW DOSE ENTECAVIR FORMULATION AND USE | BRISTOL MYERS SQUIBB CO (US) | 2005-12-14 | — | — | EP | claimed |
| EP-0835102-B1 | CONTROLLED RELEASE FORMULATION HAVING A PREFORMED PASSAGEWAY | ANDRX PHARMACEUTICALS INC (US) | 2005-01-19 | — | — | EP | claimed |
| EP-1098635-B1 | ENTERIC COATED PHARMACEUTICAL TABLET CONTAINING DIDANOSINE | BRISTOL MYERS SQUIBB CO (US) | 2004-06-02 | — | — | EP | claimed |
| EP-1221987-B1 | FLUID ABSORBING, ADHESIVE HYDROCOLLOID COMPOSITIONS | AVERY DENNISON CORP (US) | 2003-04-02 | — | — | EP | claimed |
| EP-0670718-B1 | PULSATILE PARTICLES DRUG DELIVERY SYSTEM | ANDRX PHARMACEUTICALS INC (US) | 2001-10-10 | — | — | EP | claimed |
| EP-3119475-A1 | USE OF A TORASEMIDE-BASED VETERINARY COMPOSITION FOR LOW-DOSE ADMINISTERING | Virbac (FR) | 2017-01-25 | — | — | EP | disclosed |
| WO-2015140747-A1 | USE OF A TORASEMIDE-BASED VETERINARY COMPOSITION FOR LOW-DOSE ADMINISTERING | VIRBAC (FR) | 2015-09-24 | — | — | WO | disclosed |
| EP-1441698-A4 | FLASHMELT ORAL DOSAGE FORMULATION | BRISTOL MYERS SQUIBB CO (US) | 2008-08-13 | — | — | EP | disclosed |
| EP-1441698-A1 | FLASHMELT ORAL DOSAGE FORMULATION | Bristol-Myers Squibb Company (US) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003030868-A1 | FLASHMELT ORAL DOSAGE FORMULATION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-04-17 | — | — | WO | disclosed |