Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 9/20 | 0.35 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 9/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.34 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL244111 | 1.00 | ADORA2A (0.35) | ADORA2AEML4ALKADORA3HRH4 | |
| Trifluoroacetic Acid SCHEMBL242934 | 0.91 | ADORA2A (0.41) | ADORA2AEML4ALKADORA3HRH4 | |
| SCHEMBL242379 | 0.89 | EHMT2 (0.38) | ADORA2AEML4ALKADORA3EHMT2 | |
| SCHEMBL244448 | 0.89 | EHMT2 (0.38) | ADORA2AEML4ALKADORA3EHMT2 | |
| SCHEMBL244570 | 0.85 | ADORA2A (0.49) | ADORA2AADORA3ADORA1 | |
| SCHEMBL241814 | 0.85 | ADORA3 (0.34) | ADORA2AEML4ALKADORA3HRH4 | |
| SCHEMBL243066 | 0.85 | ADORA2A (0.46) | ADORA2AEML4ALKADORA3HRH4 | |
| SCHEMBL242189 | 0.85 | ADORA2A (0.42) | ADORA2AADORA3ADORA1 | |
| SCHEMBL243200 | 0.85 | ADORA2A (0.42) | ADORA2AADORA3ADORA1 | |
| SCHEMBL242700 | 0.84 | ADORA2A (0.37) | ADORA2AEML4ALKADORA3HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8258141-B2 | Organic compounds | NOVARTIS AG (CH) | 2012-09-04 | — | — | US | disclosed |
| EP-2013211-B1 | PURINE DERIVATIVES FOR USE AS ADENOSIN A2A RECEPTOR AGONISTS | NOVARTIS AG (CH) | 2012-03-14 | — | — | EP | disclosed |
| US-20120004247-A1 | ORGANIC COMPOUNDS | NOVARTIS AG | 2012-01-05 | — | — | US | disclosed |
| EP-2322525-A1 | Purine derivatives for use as adenosin A2A receptor agonists | Novartis AG (CH) | 2011-05-18 | — | — | EP | disclosed |
| US-20100286126-A1 | Organic Compounds | NOVARTIS AG (CH) | 2010-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286126-A1 | Organic Compounds | CYP3A43, SLCO1B3, CYP2C19 | ADORA2A 2741/4885EML4 1288/4885ALK 489/4885 |
| US-20120004247-A1 | ORGANIC COMPOUNDS | CYP3A43, SLCO1B3, CYP2C19 | ADORA2A 2741/4885EML4 1288/4885ALK 489/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.