Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Esmethadone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 6/20 | 1.00 |
| ▸ | GRIN1 | Q05586 | 6/20 | 1.00 |
| ▸ | GRIN2A | Q12879 | 6/20 | 1.00 |
| ▸ | GRIN2D | O15399 | 5/20 | 1.00 |
| ▸ | GRIN2C | Q14957 | 5/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 5/20 | 1.00 |
| ▸ | GRIN2B | Q13224 | 4/20 | 1.00 |
| ▸ | DRD3 | P35462 | 3/20 | 1.00 |
| ▸ | OPRD1 | P41143 | 3/20 | 1.00 |
| ▸ | DRD4 | P21917 | 2/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 2/20 | 1.00 |
| ▸ | MRGPRX2 | Q96LB1 | 2/20 | 1.00 |
| ▸ | CACNA1F | O60840 | 1/20 | 1.00 |
| ▸ | ABCB1 | P08183 | 1/20 | 1.00 |
| ▸ | CYP2B6 | P20813 | 1/20 | 1.00 |
| ▸ | CACNA1D | Q01668 | 1/20 | 1.00 |
| ▸ | CACNA1S | Q13698 | 1/20 | 1.00 |
| ▸ | CACNA1C | Q13936 | 1/20 | 1.00 |
| ▸ | DRD2 | P14416 | 1/20 | 0.60 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methadone SCHEMBL17008675 | 1.00 | GRIN1 (1.00) | GRIN1GRIN2AOPRM1GRIN2DGRIN2C | |
| Levomethadone SCHEMBL147864 | 1.00 | GRIN1 (1.00) | GRIN1GRIN2AOPRM1GRIN2DGRIN2C | |
| Levomethadone SCHEMBL8506268 | 1.00 | GRIN1 (1.00) | GRIN1GRIN2AOPRM1GRIN2DGRIN2C | |
| Methadone SCHEMBL34140 | 1.00 | GRIN1 (1.00) | GRIN1GRIN2AOPRM1GRIN2DGRIN2C | |
| Levomethadone SCHEMBL396161 | 0.98 | GRIN1 (0.97) | GRIN1GRIN2AOPRM1GRIN2DGRIN2C | |
| Methadone SCHEMBL24293 | 0.98 | GRIN1 (0.97) | GRIN1GRIN2AOPRM1GRIN2DGRIN2C | |
| Methadone SCHEMBL7759396 | 0.98 | GRIN1 (0.97) | GRIN1GRIN2AOPRM1GRIN2DGRIN2C | |
| Methadone SCHEMBL7787108 | 0.98 | GRIN1 (0.97) | GRIN1GRIN2AOPRM1GRIN2DGRIN2C | |
| Methadone SCHEMBL18321925 | 0.98 | GRIN1 (0.97) | GRIN1GRIN2AOPRM1GRIN2DGRIN2C | |
| Methadone SCHEMBL7107052 | 0.98 | GRIN1 (0.97) | GRIN1GRIN2AOPRM1GRIN2DGRIN2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 28509 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3607938-B1 | PHARMACEUTICAL COMPOSITION | SOVIC BRKICIC LJILJANA (HR) | 2026-05-27 | — | — | EP | claimed |
| US-12637411-B2 | Structurally modified opioids for prevention and treatment of diseases and conditions | MGGM LLC (US) | 2026-05-26 | — | — | US | claimed |
| EP-4255391-B1 | LUMINOL FOR USE IN THE TREATMENT OF SEQUELAE OF A SARS-COV-2 INFECTION | METRIOPHARM AG (CH) | 2026-05-06 | — | — | EP | claimed |
| US-12616706-B2 | Compositions and methods of use comprising substances with neural plasticity actions administered at non-psychedelic/psychotomimetic dosages and formulations | Arbormentis LLC (US) | 2026-05-05 | — | — | US | claimed |
| EP-4203942-B1 | IBRUTINIB FOR USE IN TREATING COCAINE USE DISORDER AND RELATED CONDITIONS | UNIV EMORY (US) | 2026-04-15 | — | — | EP | claimed |
| EP-3355885-B1 | POLYSUBUNIT OPIOID PRODRUGS RESISTANT TO OVERDOSE AND ABUSE | ELYSIUM THERAPEUTICS INC (US) | 2026-02-25 | — | — | EP | claimed |
| EP-3507371-B1 | COMPOSITIONS FOR TREATING DISEASES AND DISORDERS OF THE NERVOUS SYSTEM | UNIV RUTGERS (US) | 2026-01-28 | — | — | EP | claimed |
| EP-4100010-B1 | NITROXIDE COMPOUNDS FOR USE IN THE TREATMENT OF OPIOID-INDUCED RESPIRATORY DEPRESSION (OIRD) | UNIV CASE WESTERN RESERVE (US) | 2026-01-07 | — | — | EP | claimed |
| US-20250312293-A1 | ESKETAMINE FOR USE IN TREATING MAJOR DEPRESSIVE DISORDER | CLEXIO BIOSCIENCES LTD (IL) | 2025-10-09 | — | — | US | claimed |
| US-20250302973-A1 | POLYMER CONJUGATES OF DRUGS WITH CENTRAL NERVOUS SYSTEM (CNS) EFFECTS AND PERIPHERAL NMDAR BLOCKING ACTIVITY AND/OR IMMUNE SYSTEM MODULATING EFFECTS | MGGM LLC | 2025-10-02 | — | — | US | claimed |
| WO-1982001649-A1 | NEW GALENIC PREPARATION OF PHENOFIBRATE,METHOD FOR THE OBTENTION THEREOF,ITS APPLICATION AS A MEDICINE | LARUELLE CLAUDE | 1982-05-27 | — | — | WO | claimed |
| EP-0000820-B1 | PROCESS FOR OBTAINING LARGE GRANULE STARCH PROTECTIVE MATERIAL FOR PRESSURE SENSITIVE MICROENCAPSULATED COATINGS | A.E. STALEY MANUFACTURING COMPANY (US) | 1982-03-31 | — | — | EP | claimed |
| EP-0006362-B1 | PROCESS FOR THE PRODUCTION OF NON-COMBUSTIBLE ASBESTOS-FREE BOARD PRODUCTS | T&N Materials Research Limited (GB) | 1982-01-13 | — | — | EP | claimed |
| EP-0037300-A1 | Whipping compositions and dessert products and method for their preparation | RHONE-POULENC SPECIALITES CHIMIQUES (FR) | 1981-10-07 | — | — | EP | claimed |
| EP-0007801-B1 | A PROCESS FOR PREPARING A STABLE, HIGH SURFACE ALPHA-ALUMINA FROM GAMMA-ALUMINA | EXXON RESEARCH AND ENGINEERING COMPANY (US) | 1981-08-26 | — | — | EP | claimed |
| EP-0031050-A2 | Process for preparing a pulverulent starchy foodstuff easily miscible with water | SOCIETE DES PRODUITS NESTLE S.A. (CH) | 1981-07-01 | — | — | EP | claimed |
| EP-0015236-A1 | Incombustible adhesive-binder composition based on alkali silicate, process for its production, and application | Société de Diffusion de Recherches Techniques et Financières S.A. (CH) | 1980-09-03 | — | — | EP | claimed |
| EP-0006390-A1 | Process of forming a fibrous web by the papermaking technique in order to improve the binding and retention, web obtained by this process and its use as a substitute material for asbestos products and as a printing or writing support | ARJOMARI-PRIOUX S.A. (FR) | 1980-01-09 | — | — | EP | claimed |
| US-4175119-A | Composition and method to prevent accidental and intentional overdosage with psychoactive drugs | PORTER GARRY L | 1979-11-20 | — | — | US | claimed |
| US-4126684-A | 4-AMINO-3-P-HALOPHENYLBUTYRIC ACIDS AND THEIR DERIVATIVES USED IN THE CONTROL OF NARCOTIC ABUSE | CIBA-GEIGY CORPORATION (US) | 1978-11-21 | — | — | US | claimed |