Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methadone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 6/20 | 1.00 |
| ▸ | GRIN1 | Q05586 | 6/20 | 1.00 |
| ▸ | GRIN2A | Q12879 | 6/20 | 1.00 |
| ▸ | GRIN2D | O15399 | 5/20 | 1.00 |
| ▸ | GRIN2C | Q14957 | 5/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 5/20 | 1.00 |
| ▸ | GRIN2B | Q13224 | 4/20 | 1.00 |
| ▸ | DRD3 | P35462 | 3/20 | 1.00 |
| ▸ | OPRD1 | P41143 | 3/20 | 1.00 |
| ▸ | DRD4 | P21917 | 2/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 2/20 | 1.00 |
| ▸ | MRGPRX2 | Q96LB1 | 2/20 | 1.00 |
| ▸ | CACNA1F | O60840 | 1/20 | 1.00 |
| ▸ | ABCB1 | P08183 | 1/20 | 1.00 |
| ▸ | CYP2B6 | P20813 | 1/20 | 1.00 |
| ▸ | CACNA1D | Q01668 | 1/20 | 1.00 |
| ▸ | CACNA1S | Q13698 | 1/20 | 1.00 |
| ▸ | CACNA1C | Q13936 | 1/20 | 1.00 |
| ▸ | DRD2 | P14416 | 1/20 | 0.60 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Esmethadone SCHEMBL24294 | 1.00 | GRIN1 (1.00) | GRIN1GRIN2AOPRM1GRIN2DGRIN2C | |
| Methadone SCHEMBL17008675 | 1.00 | GRIN1 (1.00) | GRIN1GRIN2AOPRM1GRIN2DGRIN2C | |
| Levomethadone SCHEMBL147864 | 1.00 | GRIN1 (1.00) | GRIN1GRIN2AOPRM1GRIN2DGRIN2C | |
| Levomethadone SCHEMBL8506268 | 1.00 | GRIN1 (1.00) | GRIN1GRIN2AOPRM1GRIN2DGRIN2C | |
| Levomethadone SCHEMBL396161 | 0.98 | GRIN1 (0.97) | GRIN1GRIN2AOPRM1GRIN2DGRIN2C | |
| Methadone SCHEMBL24293 | 0.98 | GRIN1 (0.97) | GRIN1GRIN2AOPRM1GRIN2DGRIN2C | |
| Methadone SCHEMBL7759396 | 0.98 | GRIN1 (0.97) | GRIN1GRIN2AOPRM1GRIN2DGRIN2C | |
| Methadone SCHEMBL7787108 | 0.98 | GRIN1 (0.97) | GRIN1GRIN2AOPRM1GRIN2DGRIN2C | |
| Methadone SCHEMBL18321925 | 0.98 | GRIN1 (0.97) | GRIN1GRIN2AOPRM1GRIN2DGRIN2C | |
| Methadone SCHEMBL7107052 | 0.98 | GRIN1 (0.97) | GRIN1GRIN2AOPRM1GRIN2DGRIN2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 51058 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4747639-A2 | BETA-GALACTOSIDASE ENZYME-BASED IMMUNOASSAY | Abbott Diagnostics Scarborough, Inc. (US) | 2026-05-27 | — | — | EP | claimed |
| EP-3607938-B1 | PHARMACEUTICAL COMPOSITION | SOVIC BRKICIC LJILJANA (HR) | 2026-05-27 | — | — | EP | claimed |
| CN-122094963-A | Cardioprotective lipids and methods of use | — | 2026-05-26 | — | — | CN | claimed |
| CN-122072257-A | Method for rapidly detecting poison in blood | 中国科学院大连化学物理研究所 | 2026-05-22 | — | — | CN | claimed |
| US-20260141998-A1 | METHOD FOR TRACKING, VERIFYING, AND AUTHENTICATING MULTI-STAGE CHAIN OF CUSTODY | Courtfact, LLC (US) | 2026-05-21 | — | — | US | claimed |
| CN-120577280-B | Drug qualitative detection method based on multi-concentration mixed SERS data | 南通大学 | 2026-05-19 | — | — | CN | claimed |
| EP-4734974-A1 | CANNABINOID COMPOSITION FOR USE IN THE TREATMENT OF PAIN AND/OR INFLAMMATION | Mabewo Phytopharm AG (CH) | 2026-05-06 | — | — | EP | claimed |
| EP-4255391-B1 | LUMINOL FOR USE IN THE TREATMENT OF SEQUELAE OF A SARS-COV-2 INFECTION | METRIOPHARM AG (CH) | 2026-05-06 | — | — | EP | claimed |
| US-12617809-B2 | Cardioprotective lipid and method of use | SIGNPATH PHARMA, INC. (US) | 2026-05-05 | — | — | US | claimed |
| WO-2026090360-A1 | FUSED PYRIMIDINE COMPOUNDS FOR TREATMENT OF TINNITUS, HEARING LOSS, AND MENIERE'S DISEASE | OVID THERAPEUTICS INC. (US) | 2026-04-30 | — | — | WO | claimed |
| US-4242274-A | DIPHENYLACETONITRILE, 1-(DIMETHYLAMINO)-2-HALOPROPANE, A BASE, WATER, A SOLVENT, AND A QUATERNARY CATALYST | MALLINCKRODT, INC. (US) | 1980-12-30 | — | — | US | claimed |
| US-4223004-A | DETECTING UNAUTHORIZED SUPPLEMENTAL DOSAGES USING DRUG AND AN ISOTOPICALLY DISTINCT ANALOG | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 1980-09-16 | — | — | US | claimed |
| US-4126684-A | 4-AMINO-3-P-HALOPHENYLBUTYRIC ACIDS AND THEIR DERIVATIVES USED IN THE CONTROL OF NARCOTIC ABUSE | CIBA-GEIGY CORPORATION (US) | 1978-11-21 | — | — | US | claimed |
| US-4110078-A | CHLOROPLATINIC ACID, COBALTOUS THIOCYANATE, HYDROCARBON LIQUID | ZELONIS PAUL THOMAS | 1978-08-29 | — | — | US | claimed |
| US-4104367-A | ANTIGEN, ANTIBODY, LABELLED METHADONE DERIVATIVE | HOFFMANN-LA ROCHE INC. (US) | 1978-08-01 | — | — | US | claimed |
| US-4064228-A | Antigens and immunoassays for morphine and related 3-oxybenzomorphan compounds | BIOLOGICAL DEVELOPMENTS, INC. (US) | 1977-12-20 | — | — | US | claimed |
| US-4022878-A | NATIVE HOMOLOGOUS HAPTEN OR ANTIGEN | BIOLOGICAL DEVELOPMENTS, INC. (US) | 1977-05-10 | — | — | US | claimed |
| US-3980766-A | METHADONE OR ITS SALTS, INJESTIBLE SOLIDS | WEST LABORATORIES, INC. (US) | 1976-09-14 | — | — | US | claimed |
| US-3966940-A | TREATMENT OF NARCOTICS ADDICTION | BRISTOL-MYERS COMPANY (US) | 1976-06-29 | — | — | US | claimed |
| US-3947592-A | Treatment of opiate addiction | INDIANA UNIVERSITY FOUNDATION (US) | 1976-03-30 | — | — | US | claimed |