Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 17/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2627308 | 0.79 | ALDH1A1 (0.49) | NOTUMCYP1A2CYP2C9CHRNB2CYP2B6 | |
| SCHEMBL17295779 | 0.79 | NOTUM (0.53) | NOTUMCYP1A2CYP2C9CHRNB2CYP2B6 | |
| SCHEMBL19814171 | 0.79 | NOTUM (0.61) | NOTUMCYP1A2CYP2C9CHRNB2CYP2B6 | |
| SCHEMBL30462844 | 0.79 | NOTUM (0.53) | NOTUMCYP1A2CYP2C9CHRNB2CYP2B6 | |
| SCHEMBL20409480 | 0.79 | NOTUM (0.45) | NOTUMCYP1A2CYP2C9CHRNB2CYP2B6 | |
| SCHEMBL22704548 | 0.79 | NOTUM (0.47) | NOTUMCYP1A2CYP2C9CHRNB2CYP2B6 | |
| SCHEMBL2627229 | 0.76 | NOTUM (0.44) | NOTUMCYP1A2CYP2C9CHRNB2CYP2B6 | |
| SCHEMBL31285600 | 0.76 | ALDH1A1 (0.49) | NOTUMKEAP1EGLN2 | |
| SCHEMBL1039243 | 0.76 | NR4A1 (0.51) | NOTUMCYP1A2CYP2C9CHRNB2CYP2B6 | |
| SCHEMBL20265273 | 0.76 | KDM4E (0.55) | NOTUMCYP1A2CYP2C9CHRNB2CYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3971176-A1 | AROMATIC AMINE AR AND BET TARGETING PROTEIN DEGRADATION CHIMERA COMPOUND AND USE | Hinova Pharmaceuticals Inc. (CN) | 2022-03-23 | — | — | EP | disclosed |