⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12492234 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL30296787 | 0.97 | — | — | |
| Hydrochloric Acid SCHEMBL17473481 | 0.97 | — | — | |
| SCHEMBL24413796 | 0.87 | — | — | |
| SCHEMBL21129684 | 0.87 | — | — | |
| SCHEMBL24469569 | 0.84 | SLC6A3 (0.38) | — | |
| SCHEMBL6625253 | 0.84 | SLC6A3 (0.38) | — | |
| SCHEMBL23590625 | 0.82 | SLC6A3 (0.33) | — | |
| SCHEMBL23083514 | 0.80 | KDM4E (0.31) | — | |
| SCHEMBL28984066 | 0.80 | KDM4E (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116731046-B | High-activity HPK1 kinase inhibitor | 杭州阿诺生物医药科技有限公司 | 2025-06-03 | — | — | CN | disclosed |
| CN-114555565-B | Nitrogen-containing heterocyclic compound, preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2024-03-05 | — | — | CN | disclosed |
| US-20230399327-A1 | HIGH ACTIVITY HPK1 KINASE INHIBITOR | ADLAI NORTYE BIOPHARMA CO., LTD. (CN) | 2023-12-14 | — | — | US | disclosed |
| CN-117024445-A | Compounds for preparing HPK1 kinase inhibitor and synthesis method thereof | 杭州阿诺生物医药科技有限公司 | 2023-11-10 | — | — | CN | disclosed |
| CN-116731046-A | High-activity HPK1 kinase inhibitor | 杭州阿诺生物医药科技有限公司 | 2023-09-12 | — | — | CN | disclosed |
| CN-116685585-A | High-activity HPK1 kinase inhibitor | 杭州阿诺生物医药科技有限公司 | 2023-09-01 | — | — | CN | disclosed |
| CN-114555565-A | Nitrogen-containing heterocyclic compound, preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2022-05-27 | — | — | CN | disclosed |
| WO-2022089398-A1 | HIGH ACTIVITY HPK1 KINASE INHIBITOR | 杭州阿诺生物医药科技有限公司 | 2022-05-05 | — | — | WO | disclosed |
| WO-2021114691-A1 | NITROGEN-CONTAINING RING-FUSED COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2021-06-17 | — | — | WO | disclosed |
| US-8012956-B2 | Tropane compounds | EXELIXIS, INC. (US) | 2011-09-06 | — | — | US | disclosed |
| WO-2011058766-A1 | ARYL CARBOXAMIDE DERIVATIVES AS TTX-S BLOCKERS | RAQUALIA PHARMA INC. (JP) | 2011-05-19 | — | — | WO | disclosed |
| EP-2074120-B1 | TROPANE COMPOUNDS | EXELIXIS INC (US) | 2010-03-03 | — | — | EP | disclosed |
| EP-2074120-A1 | TROPANE COMPOUNDS | Exelixis, Inc. (US) | 2009-07-01 | — | — | EP | disclosed |
| US-20090163471-A1 | Tropane compounds | EXELIXIS, INC. | 2009-06-25 | — | — | US | disclosed |
| WO-2009055077-A1 | TROPANE COMPOUNDS | EXELIXIS, INC. (US) | 2009-04-30 | — | — | WO | disclosed |
| US-4102890-A | HYPNOTIC, ANALGESIC, HYPOTENSIVE, CARDIOVASCULAR DEPRESSANTS, NEURO-MODULATORS | SCIENCE-UNION ET CIE, SOCIETE FRANCAISE DE RECHERCHE MEDICALE (FR) | 1978-07-25 | — | — | US | disclosed |